Table 2.

Effect of dietary tocopherol treatment on histology of ACF with 4 or more ACs

GroupTotal ACF analyzedHyperplasia (%)Low-grade dysplasia (%)High-grade dysplasia (%)pa
Control4316 (37.2)13 (30.2)14 (32.6)
0.2% α-T4118 (43.9)12 (29.3)11 (26.8)0.79
0.2% γ-T4325 (58.1)10 (23.3)8 (18.6)0.14
0.2% δ-T3827 (71.1)7 (18.4)4 (10.5)0.01b
0.2% γ-TmT4023 (57.5)10 (25.0)7 (17.5)0.14
0.2% γ-TmT*4421 (47.7)12 (27.3)9 (20.5)0.41

γ-TmT*, rats were switched to diet containing 0.2% γ-TmT 1 day after the second AOM treatment.

  • aχ2 test was used to analyze the difference between the positive control and treatment groups.

  • bThe percentage of ACF with dysplasia was significantly lower than the positive control (P < 0.01).