Table 1.

Effect of dietary tocopherol treatments on ACF formation in AOM-treated F344 rats

GroupTotal ACF No./ratTotal AC No./ratNumber of foci containing
1 AC2 AC3 AC≥4 AC
Control237.0 ± 13.3a554.5 ± 64.4a82.4 ± 19.2a,b72.7 ± 15.0a50.7 ± 10.8a31.2 ± 9.0a
0.2% α-T220.7 ± 25.5a466.3 ± 94.2b89.7 ± 20.8a70.0 ± 18.9a38.1 ± 11.5a,b26.3 ± 8.0a
0.2% γ-T126.8 ± 24.8c291.9 ± 60.0c38.8 ± 9.5c43.1 ± 10.0b,c28.6 ± 8.6c16.3 ± 4.7b
0.2% δ-T89.3 ± 29.2d205.5 ± 69.1d23.9 ± 8.2c31.9 ± 12.2c21.0 ± 8.7c12.5 ± 6.2b
0.2% γ-TmT124.0 ± 20.0c274.7 ± 60.1c49.8 ± 11.5c44 ± 4.4b24.8 ± 7.0c13.6 ± 2.9b
0.2% γ-TmT*151.1 ± 28.2b304.3 ± 67.7c67.8 ± 25.2b41.7 ± 12.3b,c26.2 ± 11.3c15.4 ± 6.4b

NOTE. Values are mean ± SD. n = 10.

γ-TmT*, rats switched to diet containing 0.2% γ-TmT 1 day after the second AOM injection.

  • a,b,c,dSignificant statistical difference by 1-way ANOVA followed by the Duncan post hoc test.