Table 3.

Cox proportional hazards models on time to progression

Prospective cohort (N = 296)Retrospective cohort (N = 116)
AnalysisVariableHR (95% CI)PC-index (95% CI)HR (95% CI)PC-index (95% CI)
Previous models
Model 13p and/or 9p LOHa22.6 (3.1–164.5)0.0020.66 (0.47–0.81)21.1 (2·9–155·8)0.0030.70 (0.48–0.86)
Model 23p and/or 9p LOHa18.5 (2.5–135.3)0. 0040.75 (0.56–0.87)14.4 (1.9–111.7)0.010.77 (0.53–0.91)
High-risk site2.5 (1.2–5.6)0.021.9 (0.8—4.7)0.16
Non-smoker1.8 (1.0—3.4)0.061.8 (0.8–4.2)0.17
Current models
Model 3Intm-risk LOHb11.6 (2.7–49.9)0.0010.79 (0.59–0.91)3.4 (1.4–8.2)0.0060·68 (0·46–0·84)
High-risk LOHc52.1 (11.8–230.6)<0.00111.2 (3.3–38.6)<0.001
Model 4Intm-risk LOHb9.7 (2.2–42.0)0.0030.81 (0. 61–0.92)3.2 (1.1–9.4)0.04
High-risk LOHc41.7 (9.3–187.6)<0.0017.6 (1.8–32.6)0.0070.75 (0·51–0.90)
High-risk site1.8 (0.8–4.0)0.162.2 (0.8–5.7)0.12
Nonsmoker2.0 (1.0–3.8)0.051.7 (0.7–4.1)0.21
  • aHigh-risk LOH: (3p &/or 9p LOH) compared with low-risk (3p and 9p R).

  • bIntm-R (Intermediate-risk LOH): (9pLOH only or with either 17pLOH or 4qLOH but not both) compared with low-risk (9pR).

  • cHigh-risk LOH: (9pL and 4qL and 17pL).