Table 1.

Human primary prostate epithelial cellular proteins differentially expressed due to lycopene treatment

Accession numberProteinUnique peptidesFold change (P ≤ 0.05)Function
Cytosol/membrane (nonnuclear)
Apoptosis
IPI00021263Protein kinase C inhibitor protein 170.85 ± 0.13Antiapoptosis process
IPI00304925Heat shock 70 kDa protein 1A/1B60.88 ± 0.10Antiapoptosis process
IPI00025512HSPβ-140.90 ± 0.04Antiapoptosis process
IPI00003815Rho GDP-dissociation inhibitor 130.89 ± 0.09Antiapoptosis process
IPI00550900Translationally controlled tumor protein20.90 ± 0.07Antiapoptosis process
IPI00220766Lactoylglutathione lyase40.87 ± 0.01Antiapoptosis process
IPI0000336278 kDa glucose-regulated protein140.84 ± 0.09Antiapoptosis process
IPI00007074Tyrosyl-tRNA synthetase31.20 ± 0.09Induction of apoptosis
IPI0001125340S ribosomal protein S361.15 ± 0.07Activation of caspase and induction of apoptosis
IPI00479186Pyruvate kinase isozymes M2191.15 ± 0.07Nuclear translocation induction of cell death
IPI00010896Chloride intracellular channel protein 160.65 ± 0.05Suppression of CLIC1 which induces apoptosis and inhibits tumor growth
Antioxidation and cytoprotection
IPI00386755ERO1-like protein alpha100.80 ± 0.06Responsible for a significant proportion of ROS
IPI00642936Glutathione S-transferase omega 141.11 ± 0.05Functions in the GSH-ascorbate cycle as part of antioxidant metabolism
IPI00009634Sulfide-quinone oxidoreductase81.13 ± 0.06Catalyzes oxidation of hydrogen sulfide with the help of a quinone
IPI00640741Peroxiredoxin-171.14 ± 0.09Reduces hydrogen peroxide and alkyl hydroperoxides
IPI00219757Glutathione S-transferase P 1101.17 ± 0.04Conjugates GSH with electrophiles
IPI00000877Hypoxia upregulated protein 141.56 ± 0.19Cytoprotective mechanisms triggered by oxygen deprivation
IPI00008223UV excision repair protein RAD23 homolog B31.49 ± 0.35Recognizes helix-distorting lesions in DNA and initiates global genome repair
Signal transduction
IPI00298547Protein DJ140.77 ± 0.13Positive regulator of androgen receptor-dependent transcription
IPI00027230HSP90β190.89 ± 0.08AR chaperone protein which stabilizes AR in the cytosol
IPI00646689Thioredoxin domain-containing protein 1730.87 ± 0.07Deficiency enhances TNF-α–induced apoptosis
IPI00293276Macrophage migration inhibitory factor20.76 ± 0.04Proinflammatory cytokine and positive regulation of ERK1 and ERK2 cascade
IPI00022078Protein NDRG141.42 ± 0.21Act as tumor suppressors in many cell types
IPI00411765Epithelial cell marker protein 170.88 ± 0.08Regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway
Nucleus
IPI00021405Prelamin-A/C70.84 ± 0.14Disrupts mitosis and induces DNA damage
IPI00411765Epithelial cell marker protein 170.84 ± 0.08Regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway