Table 2.

Ongoing clinical trials with curcumin

Trial typeOfficial titleCancer typeIdentifier number
Phase 1Phase I Study of Surface-Controlled Water Soluble Curcumin (THERACURMIN CR-011L) in Patients With Advanced MalignanciesAdvanced malignanciesSafety/efficacy studyNCT 01201694
Non-randomizedSingle group assignment
Open label
Phase 1Phase I Pharmacokinetic Trial of Curcuminoids Administered in a Capsule FormulationColon cancerPharmacokinetic studyNCT 00027495
Non-randomizedSingle group assignment
Open label
Phase 1Phase I Clinical Trial Investigating the Ability of Plant Exosomes to Deliver Curcumin to Normal and Malignant Colon TissueColon cancerBioavailability studyNCT 01294072
Randomized controlled trialFactorial assignment
RecruitingOpen label
Phase 1Crossover, Multiple Dose Pharmacokinetics of Two Curcumin Formulations in Healthy VolunteersHealthy volunteersPharmacokinetic studyNCT 01330810
Randomized controlled trialCrossover assignment
Double blind (subject, caregiver, investigator, and outcomes assessor)
Phase 1Curcumin Chemoprevention of Colorectal Neoplasia (Curcumin biomarker)Colorectal cancerPharmacodynamic studyNCT 01333917
Non-randomizedSingle group assignment intervention
Open label
Phase 1Pilot Study of Curcumin, Vorinostat, and Sorafenib in Patients With Advanced Solid TumorsAdvanced solid tumorSafety/efficacy studyNCT 01608139
Randomized controlled trialSingle group assignment
Open label
Phase 2Phase II Double Blind Placebo-Controlled Trial of Curcuminoids' Effect on Cellular Proliferation, Apoptosis and COX-2 Expression in the Colorectal Mucosa of Subjects With Recently Resected Sporadic Adenomatous PolypsColorectal cancerSafety/efficacy studyNCT 00118989
Randomized controlled trialParallel assignment
Double blind (subject and investigator)
Phase 2Phase II Trial of Curcumin in Cutaneous T-cell Lymphoma PatientsCutaneous T-cell lymphomaEfficacy studyNCT 00969085
Non-randomizedSingle group assignment open label
Phase 2Phase II Trial of Curcumin in Patients With Advanced Pancreatic CancerAdvanced pancreatic cancerSafety/efficacy studyNCT 00094445
Non-randomizedSingle group assignment open label
Phase 2Curcumin for Treatment of Intestinal Adenomas in Familial Adenomatous Polyposis (FAP)Colorectal cancerParallel assignmentNCT 00641147
Randomized controlled trialDouble blind (subject and investigator)
Recruiting
Phase 2Curcumin With Pre-operative Capecitabine and Radiation Therapy Followed by Surgery for Rectal CancerRectal cancerSafety/efficacy studyNCT 00745134
Randomized controlled trialSingle group assignment
Double blind (subject and caregiver)