Table 2.

Prediction results in microarray data

Discovery phaseIn silico validation
GoldenGate dataGSE17648GSE29490
AUCSENS80 (%)AUCSENS80 (%)AUCSENS80 (%)
AGTR10.92 (0.85–0.96)89 (78–93)0.91 (0.75–0.98)86 (59–96)0.76 (0.59–0.88)67 (42–83)
EPHA70.85 (0.78–0.90)78 (66–88)0.80 (0.61–0.93)77 (50–86)0.71 (0.52–0.85)63 (33–75)
WNT20.88 (0.81–0.93)80 (68–86)0.93 (0.79–0.99)91 (68–96)0.85 (0.69–0.95)79 (52–92)
EYA40.97 (0.93–0.99)96 (86–98)1.00 (1.00–1.00)100 (100–100)0.96 (0.82–1.00)96 (83–100)
SLIT20.97 (0.92–0.99)96 (89–99)0.89 (0.68–0.96)86 (55–96)0.83 (0.68–0.93)79 (42–92)
All loci0.98 (0.95–0.99)98 (91–99)1.00 (1.00–1.00)100 (100–100)0.95 (0.86–0.99)96 (58–100)

NOTE: For each loci and their combination, results from AUC and %sensitivity at 80% specificity (SENS80) computed in the microarray data used for markers selection (GoldenGate) and public data sets used for in silico validation. Brackets contain the corresponding intervals at 95% CI.