Table 1.

Sensitivity, specificity, PPV, NPV, and referral rates for colposcopy for endpoints CIN2+ and CIN3+ in the validation set of 218 hrHPV-positive cervical scrapes

TriageEndpointSensitivity [% (95% CI)]Specificity [% (95% CI)]PPV [% (95% CI)]NPV [% (95% CI)]Referral rate [% (95% CI)]
FAM19A4aCIN2+69.2 (56.7–81.8)69.9 (62.9–76.9)41.9 (31.4–52.3)87.9 (82.3–93.4)39.4 (33.0–45.9)
CIN3+75.8 (61.1–90.4)67.0 (60.3–73.8)29.1 (19.5–38.7)93.9 (89.9–98.0)39.4 (33.0–45.9)
CytologybCIN2+63.5 (50.4–76.5)83.7 (79.1–89.3)55.0 (42.4–67.6)88.0 (82.9–93.0)27.5 (21.6–33.5)
CIN3+63.6 (47.2–80.0)78.9 (73.0–84.4)35.0 (22.9–47.1)92.4 (88.3–96.5)27.5 (21.6–33.5)
  • aAt the threshold that gave rise to a 70% CIN3+ specificity in the training set.

  • bThreshold ASCUS.