Table 1.

Baseline characteristics and laboratory values

PlaceboSAMe
Baseline laboratory valuesnMean ± SDnMean ± SD
AFP, ng/mL4834.10 ± 27.285534.57 ± 23.85
DCP, ng/mL331.04 ± 1.78351.40 ± 3.77
AFP-L3, %327.77 ± 5.50387.75 ± 2.23
SAMe, nmol/L49121.54 ± 50.1055109.72 ± 61.93
SAH, nmol/L4936.14 ± 11.115534.33 ± 13.33
SAM/SAH493.48 ± 1.19553.33 ± 1.30
Methionine, μmol/L4940.78 ± 21.345540.83 ± 21.08
tHcy, μmol/L499.68 ± 3.12559.57 ± 2.80
tGSH, μmol/L492.08 ± 1.08552.10 ± 0.92
MDA, μmol/L493.42 ± 1.68552.94 ± 1.16
4-HNE, mg/mL491.09 ± 0.48551.08 ± 0.70
Platelets, 103/mm352121.67 ± 48.1756127.75 ± 57.28
Albumin, g/dL533.48 ± 0.45563.54 ± 0.40
Alkaline phosphatase, IU/L5299.64 ± 47.605693.89 ± 29.69
Bilirubin, mg/dL531.24 ± 0.66561.06 ± 0.45
AST, IU/L53115.78 ± 61.4256112.59 ± 60.55
ALT, IU/L53112.91 ± 77.3256112.52 ±55.91
AST/ALT531.11 ± 0.31561.05 ± 0.30
INR491.13 ± 0.15521.15 ± 0.15
HCV RNA, IU/mL482,835,799 ± 3,296,975493,373,670 ± 3,862,249
Patient characteristics
Age, y5357.25 ± 5.755758.47 ± 4.88
BMI, kg/m25329.67 ± 5.605630.15 ± 5.78
n (%)n (%)
Gender, male47 (88.7)48 (84.2)
Ethnicity, Hispanic10 (18.9)14 (24.6)
Race, Caucasian30 (56.6)33 (57.9)
 Black17 (32.1)16 (28.1)
 Asian/other/unknown6 (11.3)8 (14.0)
  • Abbreviation: INR, international normalized ratio.