Table 4.

Associations between leukoplakia claim before OCC diagnosis and stage of cancer at diagnosis

Cancer stageLocalizedRegionalDistantRegional or distant
Total, N (%)3,336 (43%)3,581 (46%)825 (11%)4,406 (57%)
No prior leukoplakia, N (%)2,942 (41%)3,411 (48%)803 (11%)4,214 (59%)
Prior leukoplakia, N (%)394 (67%)170 (29%)22 (4%)192 (33%)
OR (95% CI)Reference0.37 (0.31–0.45)0.21 (0.13–0.32)0.34 (0.29–0.41)
Adjusted OR (95% CI)aReference0.39 (0.32–0.47)0.22 (0.14–0.34)0.36 (0.30–0.43)
No prior leukoplakia, N (%)2,942 (41%)3,411 (48%)803 (11%)4,214 (59%)
Leukoplakia ≤3 mo. before cancer diagnosis, N (%)120 (70%)bb52 (30%)
OR (95% CI)Reference0.32 (0.23–0.46)0.21 (0.10–0.46)0.30 (0.22–0.42)
Adjusted OR (95% CI)aReference0.33 (0.24–0.47)0.23 (0.11–0.50)0.32 (0.23–0.44)
No prior leukoplakia, N (%)2,942 (41%)3,411 (48%)803 (11%)4,214 (59%)
Leukoplakia >3 months before cancer diagnosis, N (%)274 (66%)bb140 (34%)
OR (95% CI)Reference0.39 (0.32–0.49)0.20 (0.12–0.34)0.36 (0.29–0.44)
Adjusted OR (95% CI)aReference0.42 (0.33–0.52)0.22 (0.13–0.37)0.38 (0.31–0.47)

NOTE: The table excludes 258 cases that were diagnosed at the time of death and 944 cases that were unstaged at diagnosis. Of the unstaged cases, 43 had a prior leukoplakia claim and 901 had no prior leukoplakia claim.

  • Abbreviations: OCC, oral cavity cancer; OR, odds ratio; CI, confidence interval.

    aAdjusted for sex, race, age at cancer diagnosis, and calendar year at cancer diagnosis.

  • bTo preserve subject's anonymity, numbers and percentages are suppressed when a count of <11 can be derived, in accordance with the SEER-Medicare data use agreement.