Table 2.

Association of leukoplakia with OCC

Categories of demographic characteristics and leukoplakia statusIncidenceHR (95% CI)
OCC casesrateaUnadjustedAdjustedb
Overall
 No prior leukoplakia8,28019ReferenceReference
 Prior leukoplakia64759332.8 (29.7–36.3)31.3 (28.2–34.7)
  ≤3 months after leukoplakia2022,703115 (100–134)110 (95.3–128)
  >3 months after leukoplakia44543824.1 (21.5–27.1)23.0 (20.5–25.9)
  >12 months after leukoplakia32439922.3 (19.6–25.4)21.3 (18.6–24.3)
Women
 No prior leukoplakia3,50413ReferenceReference
 Prior leukoplakia
  >3 months after leukoplakia26845836.7 (31.5–42.8)37.3 (32.0–43.5)
  >12 months after leukoplakia19243433.0 (27.8–39.3)33.5 (28.1–39.9)
Men
 No prior leukoplakia4,77627ReferenceReference
 Prior leukoplakia
  >3 months after leukoplakia17737114.9 (12.5–17.8)14.7 (12.3–17.5)
  >12 months after leukoplakia13235614.3 (11.7–17.4)14.0 (11.5–17.1)
Age <75 years
 No prior leukoplakia4,02418ReferenceReference
 Prior leukoplakia
  >3 months after leukoplakia14727817.5 (14.6–21.0)16.7 (13.9–20.1)
  >12 months after leukoplakia9425415.4 (12.4–19.1)14.7 (11.8–18.3)
Age ≥75 years
 No prior leukoplakia4,25620ReferenceReference
 Prior leukoplakia
  >3 months after leukoplakia29853830.6 (26.4–35.4)28.6 (24.6–33.1)
  >12 months after leukoplakia23052028.4 (24.2–33.4)26.6 (22.6–31.3)
  • Abbreviations: OCC, oral cavity cancer; HR, hazard ratio; CI, confidence interval.

    aPer 100,000 person-years.

  • bAdjusted for sex, race, age, and calendar year at start of follow-up.