Table 3.

Geometric means (95% confidence intervals) of baseline urinary benzene, acrolein and crotonaldehyde mercapturic acids, prostaglandin E2 metabolite (PGEM), and 8-iso-prostaglandin F (8-iso-PGF) in smokers separated by glutathione S-transferase (GST) M1 and T1 genotypes, The PEITC Intervention Study 2008–2013

GST genotypeNaBenzene SPMA (pmol/mg Cr)bAcrolein HPMA (nmol/mg Cr)bCrotonaldehye HMPMA (nmol/mg Cr)bPGEM (pmol/mg Cr)b8-iso-PGF (pmol/mg Cr)b
GSTM1
 Null361.72 (1.22–2.40)7.12 (5.98–8.48)5.16 (4.22–6.28)41.18 (34.22–49.58)0.88 (0.76–1.02)
 Present453.10 (2.28–4.20)6.28 (5.36–7.36)4.28 (3.58–5.12)46.42 (39.26–54.88)0.82 (0.70–0.94)
P0.0140.3090.1860.3570.442
GSTT1
 Null190.80 (0.52–1.18)7.22 (5.64–9.22)5.26 (3.98–6.94)45.32 (34.90–58.86)0.78 (0.64–0.98)
 Present623.34 (2.68–4.18)6.48 (5.66–7.40)4.48 (3.86–5.22)43.58 (37.78–50.26)0.86 (0.76–0.96)
P<0.0010.4590.3380.7990.495
GSTM1 and GSTT1
 Both null120.44 (0.28–0.74)8.58 (6.26–11.74)5.76 (4.02–8.26)43.18 (30.76–60.62)0.86 (0.64–1.14)
 One present312.84 (2.12–3.82)6.28 (5.22–7.58)4.82 (3.88–5.96)42.06 (34.38–51.48)0.84 (0.72–1.00)
 Both present383.56 (2.74–4.66)6.40 (5.40–7.58)4.22 (3.48–5.12)45.88 (38.20–55.12)0.84 (0.72–0.98)
Ptrend<0.0010.2440.1300.6170.891
  • aOne subject who did not provide urine sample at baseline was excluded from all analyses.

  • bAll geometric means were adjusted for age and gender.