Table 3.

Influence of 5MeCDDO on incidence of neoplastic and hyperplastic oral lesions in rats treated with 4-NQO

Group
4-NQO/basal diet4-NQO/CDDO-ME
RouteDiet
Dietary level (mg/kg diet)0 (control)15
Microscopic tongue lesion
Squamous cell carcinoma21/28 (75%)24/29 (83%)
Carcinoma invasion score
 +11/28 (4%)1/29 (3%)
 +22/28 (7%)1/29 (3%)
 +32/28 (7%)3/29 (10%)
 +416/28 (57%)19/29 (66%)
Squamous epithelial hyperplasia4/28 (14%)5/29 (17%)
Normal3/28 (11%)0