Table 2.

Effects of 5MeCDDO and 5, 6 benzoflavone in the prevention of methylnitrosourea (MNU)-induced mammary cancers in female Sprague-Dawley rats

Mammary adenocarcinomasc
GroupNo. of ratsCarcinogenaTreatmentbPercent incidenceNumber/ratd,eAvg. weight of cancers (g)e,f
115MNU5MeCDDO1008.0 (86%↑)g19.2 (126%↑)g
215MNUNone934.38.5
  • aFemale Sprague-Dawley rats received MMNU at 50 days of age.

  • b5MeCDDO was administered one week after MNU.

  • cData on mammary cancers were obtained at necropsy of the rats (126 days after MNU).

  • dNumbers in parenthesis are percent differences from control group (Group 2).

  • eTumor multiplicity different from Group 2.

  • fTumor weight different from Group 2.

  • gP < 0.05.