Table 1.

Baseline characteristics of randomized participants

Control (n = 87)Diet (n = 118)Exercise (n = 117)Diet + Exercise (n = 117)All participants
Mean (SD)Mean (SD)Mean (SD)Mean (SD)(n = 438)a
Age (years)57.4 (4.4)58.1 (6.0)58.1 (5.0)58.0 (4.5)57.9 (5.0)
BMI (kg/m2)30.7 (3.9)31.1 (3.9)30.7 (3.7)31.0 (4.3)30.9 (4.0)
Waist circumference (cm)94.83 (10.2)94.61 (10.2)95.05 (10.1)93.71 (9.9)94.5 (10.1)
VO2max (kg/mL/min)23.1 (4.1)22.7 (3.8)22.5 (4.1)23.6 (4.1)22.9 (4.03
Usual physical activity (min/wk)23.8 (41.2)33.6 (45.5)37.7 (43.7)32.4 (42.9)32.4 (43.6)
Total calories (kcal/d)1988 (669)1884 (661)1986 (589)1894 (638)1935 (637.9)
n (%)n (%)n (%)n (%)n (%)
Race/ethnicity
Non-Hispanic White74 (85.1)101 (85.6)98 (83.8)100 (85.4)372 (84.9)
African American6 (6.9)9 (7.6)15 (12.8)5 (4.3)35 (8.0)
Hispanic/Latino3 (3.4)2 (1.7)2 (1.7)5 (4.3)12 (2.7)
Other4 (4.6)6 (5.1)2 (1.7)7 (6.0)19 (4.3)
Education
College graduate and above59 (67.8)76 (64.4)70 (59.8)81 (69.8)286 (65.3)
Medication use
Statins19 (21.8)10 (8.5)19 (16.2)25 (21.6)73 (16.7)
NSAID26 (29.9)51 (43.2)36 (30.8)44 (37.9)157 (35.8)
Smoker (ever)32 (36.8)55 (46.6)47 (40.2)47 (40.5)181 (41.3)
AnalytesMean (SD)Mean (SD)Mean (SD)Mean (SD)Mean (SD)
Ox-LDL (U/L)104.9 (40.45) n=87112.4 (36.40) n=118111.3 (46.20) n=116105.9 (32.89) n=116108.9 (39.20) n=437
FOP (FI milliunits/mL)64.03 (175.9) n=8745.71 (99.28) n=11881.35 (217.6) n=11647.41 (73.53) n=11659.27 (151.3) n=437
F2-isprostane (pg/mL)62.93 (31.09) n=8364.91 (32.77) n=10667.79 (32.32) n=10861.47 (28.75) n=10864.36 (31.26) n=405
  • aDifferences in the final number of analytes are due to the following:

  • Omitted 33 analytes from the F2-isoprostanes assay, as they failed assay quality control (n = 4 control arm; n = 9 exercise arm; n = 12 diet arm; n = 8 diet + exercise arm); one participant randomized to the diet + exercise arm was missing a baseline blood sample (n = 1); two participants randomized to the diet arm and to the exercise arm were missing a 12-month serum sample (n = 2). Finally, one participant randomized to the exercise arm was missing a 12-month plasma sample (n = 1).