Table 3.

Change in biomarker levels in BAL fluid from baseline (pre) to 6 months postintervention

Difference in post and pre levels; Median (range)
myo-InositolPlaceboPa
IL6, pg/mL−0.68 (−2.78 to 0.34)−0.27 (−1.54 to 1.89)0.03
GSH, μmol/L−0.246 (−1.98 to 0.48)−0.558 (−1.13 to 0.33)0.06
MPO, ng/mL−3.457 (−8.17 to 2.77)−1.154 (−8.43 to 1.21)0.06
CC16, ng/mL−66.962 (−127.56 to 52.26)−54.323 (−144.65 to 140.84)0.10
SFTPD, ng/mL−12.387 (−47.12 to 5.72)7.213 (−7.62 to 23.79)0.22
CCL-18, ng/mL−121.470 (−1234.7 to 1122.9)10.702 (−684.95 to 683.25)0.63
CCL-2, pg/mL−9.2465 (−44.32 to 8.62)9.413 (−52.58 to 54.6)0.58
  • Abbreviations: CCL-2, chemokine ligand 2 (previously known as monocyte chemotactic protein 1); CCL-18, chemokine ligand 18 (previously known as pulmonary and activation-regulated chemokine); GSH, total glutathione; MPO, myeloperoxidase, SFTPD, surfactant protein D.

  • aWilcoxon rank-sum P value (for difference in absolute change by arm).