Table 2.

Log-binomial univariate and multivariable model of the association between sociodemographic and clinical factors and chemoprevention use; multivariable model adjusted for age, race/ethnicity, family history, HRT use, and medical oncology referral

CharacteristicsUnivariate RR (95% CI)PMultivariable RR (95% CI)P
Breast histologyAtypical hyperplasiaReference
LCIS1.62 (1.25–2.09)0.00021.43 (1.16–1.76)0.0009
DCIS2.34 (1.89–2.90)<0.00011.54 (1.28–1.86)<0.0001
Age<45 years0.63 (0.42–0.95)0.02720.61 (0.42–0.87)0.0069
45–54 yearsReference
55–64 years1.29 (1.07–1.58)0.00721.27 (1.10–1.47)0.0012
65–74 years1.26 (1.02–1.56)0.02891.22 (1.05–1.43)0.0116
75+0.89 (0.67–1.18)0.41631.06 (0.85–1.31)0.6119
MenopauseNoReference
Yes1.47 (1.23–1.76)<0.0001
Race and ethnicityNon-Hispanic whiteReference
Non-Hispanic black1.33 (1.06–1.67)0.01530.99 (0.85–1.16)0.9076
Hispanic1.25 (1.05–1.48)0.01141.10 (0.99–1.22)0.075
Asian1.42 (1.09–1.84)0.00870.99 (0.82–1.18)0.8942
Other0.49 (0.36–0.67)<0.00010.92 (0.72–1.19)0.5403
BMI (kg/m2)<18.50.63 (0.33–1.19)0.1524
18.5–24.99Reference
25–29.991.12 (0.93–1.34)0.2303
30+1.25 (1.05–1.50)0.0112
Unknown0.19 (0.11–0.32)<0.0001
Family history of breast cancerNoReference
Yes2.40 (2.09–2.76)<0.00010.98 (0.87–1.09)0.6526
HysterectomyNoReference
Yes1.06 (0.68–1.65)0.7935
ComorbiditiesaNoReference
DVT/PE/stroke0.71 (0.38–1.32)0.2833
Uterine cancer1.01 (0.39–2.62)0.9758
HRT useNoReference
Yes2.85 (2.43–3.35)<0.00011.04 (0.90–1.19)0.5941
Medical oncology referralNoReference
Yes6.14 (5.16–7.32)<0.00015.79 (4.80–6.98)<0.0001

NOTE: Bold values indicate meeting a threshold for statistical significance.

  • aDeep vein thrombosis (DVT) and pulmonary embolism (PE).