Table 1.

Baseline characteristics of women diagnosed with atypical hyperplasia and LCIS or DCIS at CUMC, New York, NY (2007–2015)

No chemopreventionChemopreventionTotal
Characteristics(n = 1,214; 70.62%)(n = 505; 29.38%)(n = 1,719, %)P
Breast histologyAtypical hyperplasia420 (34.60)83 (13.44)503 (29.26)
LCIS294 (24.22)107 (21.19)401 (23.33)
DCIS500 (41.19)315 (62.38)815 (47.41)<0.0001
AgeMean age - years (SD)60.11 (12.61)60.48 (9.95)60.22 (11.88)
<45 years114 (9.39)23 (4.55)137 (7.97)
45–54 years328 (27.02)118 (23.27)446 (25.95)
55–64 years351 (28.91)185 (36.63)536 (31.18)
65–74 years255 (21.00)128 (25.35)383 (22.28)
75+166 (13.67)51 (10.10)217 (12.62)<0.0001
MenopauseNo420 (34.60)120 (23.76)540 (31.41)
Yes794 (65.40)385 (76.24)1,179 (68.59)<0.0001
Race and ethnicityNon-Hispanic white551 (45.39)221 (43.76)772 (44.91)
Non-Hispanic black98 (8.07)60 (11.88)158 (9.19)
Hispanic255 (21.00)142 (28.12)397 (23.09)
Asian60 (4.94)41 (8.12)101 (5.88)
Other250 (20.59)41 (8.12)291 (16.93)<0.0001
BMI (kg/m²)Mean BMI - score (SD)27.06 (6.16)28.05 (6.20)27.39 (6.19)
<18.534 (2.80)8 (1.58)42 (2.44)
18.5–24.99384 (31.63)167 (33.07)551 (32.05)
25–29.99301 (24.79)154 (30.50)455 (26.47)
30+264 (21.75)162 (32.08)426 (24.78)
Unknown231 (19.03)14 (2.77)245 (14.25)<0.0001
Family history of breast cancerNo1,120 (92.60)368 (72.87)1,488 (86.56)
Yes94 (7.74)137 (27.13)231 (13.44)<0.0001
HysterectomyNo1,183 (97.45)491 (97.23)1,674 (97.38)
Yes31 (2.55)14 (2.77)45 (2.62)0.7959
ComorbiditiesaNo1,177 (96.95)494 (97.82)1,671 (97.21)
DVT/PE/stroke30 (2.47)8 (1.58)38 (2.21)
Uterine Cancer7 (0.58)3 (0.59)10 (0.58)0.5223
HRT useNo1,204 (99.18)466 (92.28)1,670 (97.15)
Yes10 (0.82)39 (7.72)49 (2.85)<0.0001
Medical oncology referralNo1,028 (84.68)126 (24.95)1,154 (67.13)
Yes186 (15.32)379 (75.05)565 (32.87)<0.0001

NOTE: Bold values indicate meeting a threshold for statistical significance.

  • aDeep vein thrombosis (DVT) and pulmonary embolism (PE).