Table 4.

NSABP DMP-1: Comparison of characteristics related to participants' personal experience with breast cancer and the medical conditions related to taking SERMs of those who decided to take a SERM and those who decided not to take a SERM to reduce the risk of developing breast cancera

Decision about a SERM (n = 726)
To take (n = 324)Not to take (n = 402)
CharacteristicsCategoriesNo. (%)No. (%)ORb(95% CI)Pc
No. of breast biopsiesNone or unknown52 (16.0)106 (26.4)<0.001
One140 (43.2)177 (44.0)1.61 (1.08–2.40)
≥2132 (40.7)119 (29.6)2.26 (1.49–3.42)
No. of first-degree relatives with BCNone or unknown167 (51.5)162 (40.3)0.01
One117 (36.1)182 (45.3)0.62 (0.45–0.86)
≥240 (12.3)58 (14.4)0.67 (0.42–1.06)
AHNo breast biopsies52 (16.0)106 (26.4)<0.001
No breast biopsies with AH, or AH unknown64 (19.8)106 (26.4)1.23 (0.78–1.94)
At least one biopsy with AH208 (64.2)190 (47.3)2.23 (1.52–3.28)
Quartiles of 5-yr Gail risk score≤2.2660 (18.5)111 (27.6)0.007
>2.26, ≤3.1477 (23.8)107 (26.6)1.33 (0.87–2.05)
>3.14, ≤4.6291 (28.1)92 (22.9)1.83 (1.19–2.81)
>4.6296 (29.6)92 (22.9)1.93 (1.26–2.95)
Know someone in your age group with BC?No87 (26.9)101 (25.1)0.54
Yes232 (71.6)299 (74.4)0.90 (0.64–1.26)
Unknown5 (1.5)2 (0.5)
Ever had blood clotting problems?No300 (92.6)367 (91.3)0.02
Yes8 (2.5)24 (6.0)0.41 (0.18–0.92)
Unknown16 (4.9)11 (2.7)
Anyone in the family ever had bloodNo212 (65.4)239 (59.5)0.02
clotting problems?Yes94 (29.0)152 (37.8)0.70 (0.51–0.96)
Unknown18 (5.6)11 (2.7)
Know someone in your age group whoNo257 (79.3)312 (77.6)0.54
has ever had blood clotting problems?Yes64 (19.8)87 (21.6)0.89 (0.62–1.28)
Unknown3 (0.9)3 (0.7)
Ever had cataracts?No261 (80.6)331 (82.3)0.66
Yes51 (15.7)59 (14.7)1.10 (0.73–1.65)
Unknown12 (3.7)12 (3.0)
Anyone in the family ever had cataracts?No140 (43.2)156 (38.8)0.22
Yes169 (52.2)228 (56.7)0.83 (0.61–1.12)
Unknown15 (4.6)18 (4.5)
Know someone in your age group whoNo245 (75.6)308 (76.6)0.82
has ever had cataracts?Yes77 (23.8)93 (23.1)1.04 (0.74–1.47)
Unknown2 (0.6)1 (0.2)
Ever had endometrial cancer?No299 (92.3)384 (95.5)0.48
Yes5 (1.5)4 (1.0)1.61 (0.43–6.03)
Unknown20 (6.2)14 (3.5)
Anyone in the family ever hadNo274 (84.6)336 (83.6)0.21
endometrial cancer?Yes26 (8.0)44 (10.9)0.73 (0.44–1.21)
Unknown24 (7.4)22 (5.5)
Know someone in your age group whoNo298 (92.0)351 (87.3)0.05
has ever had endometrial cancer?Yes25 (7.7)48 (11.9)0.61 (0.37–1.02)
Unknown1 (0.3)3 (0.7)
  • Abbreviations: AH, atypical hyperplasia; BC, breast cancer.

  • aHeadings in bold typeface indicate items considered for multivariate modeling.

  • bOR, the relative odds for SERM uptake, “—” identifies the baseline level of the covariate.

  • cP value is based on the likelihood ratio test, unknowns were excluded for calculation of P values.