Table 5.

NSABP DMP-1: Comparison of characteristics related to participants' perceptions related to breast cancer and SERMs of those who decided to take a SERM and those who decided not to take a SERM to reduce the risk of developing breast cancera

Decision about a SERM (n = 726)
To take (n = 324)Not to take (n = 402)
CharacteristicsCategoriesNo. (%)No. (%)ORb(95% CI)Pc
Ever before thought aboutNo173 (53.4)267 (66.4)<0.001
taking a SERM?Yes150 (46.3)134 (33.3)1.73 (1.28–2.34)
Unknown1 (0.3)1 (0.2)
Ever before heard about takingNo95 (29.3)142 (35.3)0.09
a SERM to prevent BC?Yes225 (69.4)256 (63.7)1.31 (0.96–1.80)
Unknown4 (1.2)4 (1.0)
Influenced by someone'sNo171 (52.8)300 (74.6)<0.001
BC diagnosis?Yes153 (47.2)99 (24.6)2.71 (1.98–3.71)
Unknown0 (0.0)3 (0.7)
Perception on risk of developingLess than average12 (3.7)20 (5.0)<0.001
BC in the next 5 yearsAverage97 (29.9)188 (46.8)0.86 (0.40–1.83)
More than average213 (65.7)191 (47.5)1.86 (0.89–3.90)
Unknown2 (0.6)3 (0.7)
Worried about BC in theNot worried52 (16.0)126 (31.3)<0.001
next 5 years?Worried somehow76 (23.5)119 (29.6)1.55 (1.00–2.39)
Worried a lot195 (60.2)155 (38.6)3.05 (2.07–4.48)
Unknown1 (0.3)2 (0.5)
Would you change your dietNo72 (22.2)105 (26.1)0.21
to reduce BC risk?Yes252 (77.8)295 (73.4)1.25 (0.88–1.76)
Unknown0 (0.0)2 (0.5)
Would you increase exercisingNo51 (15.7)79 (19.7)0.16
to reduce BC risk?Yes273 (84.3)321 (79.9)1.32 (0.89–1.94)
Unknown0 (0.0)2 (0.5)
Would you have a mastectomyNo274 (84.6)336 (83.6)0.91
to reduce BC risk?Yes47 (14.5)59 (14.7)0.98 (0.65–1.48)
Unknown3 (0.9)7 (1.7)
Know someone with bad experienceNo278 (85.8)304 (75.6)<0.001
who took tamoxifen and/or raloxifene?Yes46 (14.2)98 (24.4)0.51 (0.35–0.76)
Know someone with good experienceNo196 (60.5)311 (77.4)<0.001
who took tamoxifen and/or raloxifene?Yes128 (39.5)91 (22.6)2.23 (1.62–3.08)
Nervous about taking a drug thatKnows someone who took drug149 (46.0)163 (40.5)<0.001
no one you know has taken?Not nervous98 (30.2)79 (19.7)1.36 (0.94–1.97)
Nervous somewhat46 (14.2)41 (10.2)1.23 (0.76–1.98)
Nervous a lot31 (9.6)119 (29.6)0.28 (0.18–0.45)
Ratings of traits of the average woman who takes a drug to prevent BCBrave or smart or healthy or takes good care of her health313 (96.6)295 (73.4)10.32 (5.44–19.59)<0.001
Scared or sickly or hypochondriac or anxious/a worrier or over medicated143 (44.1)228 (56.7)0.60 (0.45–0.81)<0.001
Scalesd,eMean (SD)Mean (SD)
Trust in the HCP44.9 (5.2)42.6 (6.2)1.07 (1.04–1.10)<0.001
Trust in pharmaceutical companies6.9 (1.7)6.2 (1.7)1.30 (1.18–1.42)<0.001
Attitudes about taking medication32.3 (5.8)28.6 (6.6)1.10 (1.07–1.13)<0.001
  • Abbreviation: BC, breast cancer.

  • aHeadings in bold typeface indicate items considered for multivariate modeling.

  • bOR, the relative odds for SERM uptake, “—” identifies the baseline level of the covariate.

  • cP value is based on the likelihood ratio test, unknowns were excluded for calculation of P values.

  • dThe "Trust in HCP" scale ranges from 10 to 50, and "Trust in pharmaceutical companies" ranges from 2 to 10, such that the higher score means a higher level of trust. The "Attitudes about taking medication" scale ranges from 9 to 45, such that the higher score means a more positive attitude.

  • eOR is per unit change.