Top signaling pathways in Inflammation and Immunity Transcriptome panel that are activated or inhibited in polyps from patients treated with sulindac–erlotinib compared with patients on placebo
| Upstream regulator | Symbol | Molecule type | z-score | P |
|---|---|---|---|---|
| Interferon alpha | IFNA | Group | 3.063 | 4.52E−22 |
| Interferon gamma | IFNG | Cytokine | 2.965 | 5.29E−21 |
| Interleukin 12 | IL12 | Complex | 2.675 | 1.55E−15 |
| Signal transducer and activator of transcription 4 | STAT4 | Transcription factor | 2.403 | 3.00E−06 |
| Prostaglandin E2 | PGE2 | Chemical | −2.225 | 1.52E−05 |
NOTE: Positive (+) z-score or negative (−) z-score indicate that these pathways are more or less active in patients treated with sulindac–erlotinib versus placebo.