Table 2.

Ingenuity (IPA) upstream regulator analysis of differentially expressed genes in endpoint polyp compared with uninvolved baseline

Placebo polyp (n = 10, 2,591 genes)Drug polyp (n = 13, 236 genes)
Upstream regulatorSymbolMolecule typez-scorePz-scoreP
Tumor necrosis factorTNFCytokine2.064.95E−161.623.08E−02
Beta-cateninCTNNB1Transcription factor3.042.29E−111.894.61E−05
Epidermal growth factorEGFGrowth factor2.383.31E−07NANS
Epidermal growth factor receptorEGFRKinase3.383.66E−051.561.80E−02
Prostaglandin E2PGE2Endogenous chemical1.951.83E−031.103.52E−02
Chromobox 5CBX5Transcription factor−3.091.90E−11−1.891.28E−04
Interferon gammaIFNGCytokine−1.173.18E−100.3931.76E−03
Caudal type homeobox 2CDX2Transcription factor−2.291.23E−090.003.85E−02
Interferon alphaIFNAGroup−3.743.78E−04−1.273.33E−02
Alpha-cateninCTNNAGroup−2.142.86E−03NANS
  • Abbreviations: NA, not applicable because upstream regulator was not significantly represented in differentially expressed gene list; NS, not significant.