Table 1C.

Summary of P valuesa for the comparison between groups within each genotype

GroupVil-Cre negative K-rasG12DK-ras wtK-rasG12DInteraction effectb
AOM-inducedNo sulindac vs. sulindac
 Total number of adenomas0.100.02<0.01<0.001
 Total tumor burden0.100.02<0.01<0.0001
 % of mice with ≥1 adenoma0.220.010.04NAc
ControlNo sulindac vs. sulindac
 Total number of adenomas1.001.000.330.17
 Total tumor burden1.001.000.330.2
 % of mice with ≥1 adenomaNANA0.45NA
SulindacControl vs. AOM-induced
 Total number of adenomas1.001.000.03<0.001
 Total tumor burden1.001.00<0.050.08
 % of mice with ≥1 adenomaNANA0.03NA
No sulindacControl vs. AOM-induced
 Total number of adenomas0.13<0.01<0.001<0.0001
 Total tumor burden0.13<0.01<0.001<0.0001
 % of mice with ≥1 adenoma0.23<0.01<0.001NA
  • aP value for the comparison between groups within each genotype derived from Wilcoxon rank sum test.

  • bP value for the interaction effects between group and genotype derived from a linear regression model for the square root transformed total number of adenomas.

  • cP value for the interaction effects between groups and genotypes derived from a logistic regression model.