Table 3.

Changes in nevus protein expression after oral administration of BSE-SFN in comparison with pretreatment

Day 28/day 0
Assigned IDProtein namePAv. ratio
22Keratin, type II cytoskeletal 1 OS = Homo sapiens GN = KRT1 PE = 1 SV = 60.0581.7
33Fibrinogen gamma chain OS = Homo sapiens GN = FGG PE = 1 SV = 30.00711.5
34Fibrinogen gamma chain OS = Homo sapiens GN = FGG PE = 1 SV = 30.0131.7
35Fibrinogen gamma chain OS = Homo sapiens GN = FGG PE = 1 SV = 30.00371.7
37Vimentin OS = Homo sapiens GN = VIM PE = 1 SV = 40.0341.8
41Septin-2 OS = Homo sapiens GN = SEPT2 PE = 1 SV = 10.0691.5
45Alpha-enolase OS = Homo sapiens GN = ENO1 PE = 1 SV = 20.0471.5
46Decorin OS = Homo sapiens GN = DCN PE = 1 SV = 10.00511.6
53Fibrinogen beta chain OS = Homo sapiens GN = FGB PE = 1 SV = 20.0151.6
58Decorin OS = Homo sapiens GN = DCN PE = 1 SV = 10.0671.5
59Delta-aminolevulinic acid dehydratase OS = Homo sapiens GN = ALAD PE = 1 SV = 10.00771.5
68Carbonic anhydrase 1 OS = Homo sapiens GN = CA1 PE = 1 SV = 20.067−1.7
69Rho GDP-dissociation inhibitor 1 OS = Homo sapiens GN = ARHGDIA PE = 1 SV = 30.0821.6
76Phosphatidylethanolamine-binding protein 1 OS = Homo sapiens GN = PEBP1 PE = 1 SV = 30.0911.7
78Peroxiredoxin-2 OS = Homo sapiens GN = PRDX2 PE = 1 SV = 50.0781.5
85Galectin-7 OS = Homo sapiens GN = LGALS7 PE = 1 SV = 20.075−1.8
87Apolipoprotein C-III OS = Homo sapiens GN = APOC3 PE = 1 SV = 10.075−1.6
  • NOTE: Six pairs of nevus tissues from days 0 and 28 (3 from 50 μmol group, 2 from 100 μmol group, and 1 from 200 μmol group) were used for proteomics by two-dimensional gel electrophoresis followed by MALDI-TOF/TOF. Altered proteins in day 28 specimens compared with day 0 specimens are listed. The cut-off criteria for selection were ≥1.5-fold difference and P value less than 0.10 by two-sided Student t test. Multiple spots for fibrinogen gamma chain and decorin suggest posttranslational modification.

  • Abbreviations: GN, gene name; OS, organism name; PE, protein existence; SV, sequence version.