Table 2.

Comparison of demographical information, clinical characteristics, and family history of cancer in patients from the HRC who tested positive versus negative for mutations

Mutation positive (n = 48)Mutation negative (n = 229)
Characteristicn (%)n (%)P value
Age
 Mean (years ± SD)56.6 (±10.95)61.07 (±10.95)0.010*
Sex
 Female22 (45.8)127 (55.5)0.223
 Male25 (54.2)102 (44.5)
Race
 White35 (72.9)200 (87.3)0.026*
 Hispanic8 (16.6)11 (4.8)
 Asian2 (4.1)11 (4.8)
 Black3 (6.2)7 (3.0)
Stage
 Localized16 (33.3)68 (29.7)0.870
 Borderline7 (14.6)33 (14.4)
 Metastatic25 (52.1)128 (55.9)
Grade of differentiation
 Well0 (0)2 (1.3)0.220
 Moderately18 (58.1)115 (72.3)
 Poorly13 (41.9)42 (26.4)
Smoking history
 Current8 (16.7)43 (18.8)0.752
 Past11 (22.9)42 (18.3)
 Never29 (60.4)144 (62.9)
Alcohol history
 Heavy1 (2.1)14 (16.1)0.244
 Occasional26 (54.2)142 (62)
 Never21 (43.8)73 (31.9)
History of pancreatitis1 (2.1)16 (7)0.322
Chronic diabetes10 (20.8)36 (15.7)0.386
Personal history of cancer
 Breast13 (27.1)43 (18.8)0.192
 Gynecologic2 (4.2)17 (7.4)0.543
 Melanoma2 (4.2)7 (3.1)0.657
 Colon3 (6.3)11 (4.8)0.715
Family history of cancer
≥1 affected FDR
 Breast23 (56.1)74 (36.8)0.021*
 Gynecologic10 (34.5)29 (17.3)0.031*
 Melanoma5 (10.4)16 (7)0.379
 Pancreas11 (23.4)52 (22.7)0.917
 Colon12 (25)28 (12.2)0.022*
≥1 affected SDR
 Breast14 (29.2)72 (31.4)0.756
 Gynecologic9 (18.8)18 (7.9)0.020*
 Melanoma1 (2.1)11 (4.8)0.698
 Pancreas7 (14.9)50 (21.8)0.284
 Colon7 (18.9)25 (13.4)0.385
  • NOTE: VUS were tabulated as negative results.

  • Abbreviations: FDR, first-degree relative; SDR, second-degree relative; *, P < 0.05.