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Read the January issue!
About the cover: The cover histological images show peri-portal fibrosis altering the microenvironment in the liver of a mouse with NASH and prevention of these histologic changes with proglumide therapy. Find out more in the article.
Research Article
Read: Targeting the Cholecystokinin Receptor: A Novel Approach for Treatment and Prevention of Hepatocellular Cancer, Martha D Gay, et al.
Commentary
Read: Clearing the Haze: What Do We Still Need to Learn about Electronic Nicotine Delivery Systems? Lisa M. Fucito, et al.
Research Article
Read: Reducing Fatty Acid Oxidation Improves Cancer-free Survival in a Mouse Model of Li-Fraumeni Syndrome, Ping-Yuan Wang, et al.
Research Article
Read: Genome-wide Association Analysis of Proinflammatory Cytokines and Gene–lifestyle Interaction for Invasive Breast Cancer Risk: The WHI dbGaP Study, Su Yon Jung, et al.

From the Current Issue

Spotlight

Implementation of Risk-reducing Strategies for Breast Cancer is Long Overdue

Victor G. Vogel

Cancer Prev Res January 1 2021 14 (1) 1-4; DOI:10.1158/1940-6207.CAPR-20-0556
Research Brief

Hallmark Circulating Tumor-Associated Cell Clusters Signify 230 Times Higher One-Year Cancer Risk

Anantbhushan Ranade, Amit Bhatt, Raymond Page, Sewanti Limaye, Timothy Crook, Dadasaheb Akolkar and Darshana Patil

Cancer Prev Res January 1 2021 14 (1) 11-16; DOI:10.1158/1940-6207.CAPR-20-0322

The study evaluated a blood test that can determine if healthy (‘asymptomatic’) individuals without a history of cancer have an increased risk of developing cancer within the next one year. This test can significantly minimize radiological or invasive screening in the majority individuals who do not have any increased risk.
Research Article

Sleep Characteristics and Risk of Ovarian Cancer Among Postmenopausal Women

Xiaoyun Liang, Holly R. Harris, Michael Hendryx, Aladdin H. Shadyab, Lauren Hale, Yueyao Li, Tracy E. Crane, Elizabeth M. Cespedes Feliciano, Marcia L. Stefanick and Juhua Luo

Cancer Prev Res January 1 2021 14 (1) 55-64; DOI:10.1158/1940-6207.CAPR-20-0174

This study shows no association between sleep duration, sleep quality, or insomnia with the risk of overall ovarian cancer among postmenopausal women. However, restful sleep quality was associated with a lower risk of invasive serous ovarian cancer, and insomnia was associated with a higher risk of invasive serous ovarian cancer.
Research Article

Association of Aspirin, Metformin, and Statin Use with Gastric Cancer Incidence and Mortality: A Nationwide Cohort Study

Mi Hee Cho, Tae Gon Yoo, Su-Min Jeong and Dong Wook Shin

Cancer Prev Res January 1 2021 14 (1) 95-104; DOI:10.1158/1940-6207.CAPR-20-0123

Long-term use of aspirin was independently associated with reduced incidence and mortality of gastric cancer in the general population. Metformin or statin use, however, was only associated with a reduction of gastric cancer mortality in diabetic patients and in the general population in a dose-response manner, respectively.
Research Article

The Acceptability and Preference of Vaginal Self-sampling for Human Papillomavirus (HPV) Testing among a Multi-ethnic Asian Female Population

Su Pei Khoo, Wen Tzien Lim, Reena Rajasuriar, Nazrila Hairizan Nasir, Patti Gravitt and Yin Ling Woo

Cancer Prev Res January 1 2021 14 (1) 105-112; DOI:10.1158/1940-6207.CAPR-20-0280

Organized cervical cancer screening remains unachievable in many countries. Self-sampling HPV testing is an evidence-based method that can remove barriers to cervical screening. This is particularly important for developing countries in order to achieve the WHO global strategy to accelerate cervical cancer elimination.
Research Article

Breast Cancer Chemoprevention: Use and Views of Australian Women and Their Clinicians

Courtney Macdonald, Christobel M. Saunders, Louise A. Keogh, Morgan Hunter, Danielle Mazza, Sue-Anne McLachlan, Sandra C. Jones, Stephanie Nesci, Michael L. Friedlander, John L. Hopper, Jon D. Emery, Martha Hickey, Roger L. Milne and Kelly-Anne Phillips; for the Kathleen Cuningham Consortium for Research Into Familial Breast Cancer

Cancer Prev Res January 1 2021 14 (1) 131-144; DOI:10.1158/1940-6207.CAPR-20-0369

Despite its efficacy in reducing breast cancer incidence, chemoprevention is underutilised. This survey study of Australian women and their clinicians used behavioural change theory to identify modifiable barriers to chemoprevention uptake, and to suggest interventions such as policy change, educational resources and public campaigns, that may increase awareness and use.