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Read the Q&A: Ned Sharpless on COVID-19 and Cancer Prevention!

Read the July issue!
The cover immunofluorescence colocalization (100 μm) image shows dopamine D2 receptors on the endothelial cells in human actinic keratosis lesions. Find out more in the aricle by Lu and colleagues.
Research Article
Read: Dopamine Prevents Ultraviolet B–induced Development and Progression of Premalignant Cutaneous Lesions through its D2 Receptors, Kai Lu, et al.
Research Article
Read: Plasma miRNA Biomarkers in Limited Volume Samples for Detection of Early-stage Pancreatic Cancer, Rachel L. Dittmar, et al.
Research Article
Read: Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis, Wensheng Zhang, et al.
Research Article
Read: The Influence of Vitamin D on Mammographic Density: Results from CALGB 70806 (Alliance) a Randomized Clinical Trial, Marie E. Wood, et al.

From the Current Issue

Commentary | AuthorChoice

The Chasm We Must Cross in Japan for Re-promotion of the HPV Vaccine

Yutaka Ueda, Kayoko Katayama, Asami Yagi and Tadashi Kimura

Cancer Prev Res July 1 2021 14 (7) 683-686; DOI:10.1158/1940-6207.CAPR-21-0091
Research Article

Dopamine Prevents Ultraviolet B–induced Development and Progression of Premalignant Cutaneous Lesions through its D₂ Receptors

Kai Lu, Madhavi Bhat, Sara Peters, Rita Mitra, Xiaokui Mo, Tatiana M. Oberyszyn, Partha Sarathi Dasgupta and Sujit Basu

Cancer Prev Res July 1 2021 14 (7) 687-696; DOI:10.1158/1940-6207.CAPR-21-0052

This investigation demonstrates the role of dopamine and its D₂ receptors in UVB induced premalignant squamous cell skin lesions and how DA through its D₂ receptors inhibits the development and progression of these lesions and subsequently prevents squamous cell carcinoma of the skin.
Research Article

Self-reported Metabolic Risk Factor Associations with Adenomatous, Sessile Serrated, and Synchronous Adenomatous and Sessile Serrated Polyps

Celina N. Santiago, Samara Rifkin, Julia Drewes, Gerard Mullin, Emma Spence, Linda M. Hylind, Joell J. Gills, David Kafonek, David M. Cromwell, Louis La Luna, Francis Giardello and Cynthia L. Sears; the Biofilm Study Consortium

Cancer Prev Res July 1 2021 14 (7) 697-708; DOI:10.1158/1940-6207.CAPR-20-0664

Self-reported medical history provides valuable insight into polyp risk, potentially enabling the use of larger retrospective studies of colonoscopy populations to assess knowledge gaps. More aggressive colonoscopy screening, critical to colorectal cancer prevention, may be considered in populations of individuals with metabolic risk factors and modifiable lifestyle risk factors.
Research Article

Oral Health and Risk of Upper Gastrointestinal Cancers in a Large Prospective Study from a High-risk Region: Golestan Cohort Study

Yukiko Yano, Christian C. Abnet, Hossein Poustchi, Gholamreza Roshandel, Akram Pourshams, Farhad Islami, Masoud Khoshnia, Taghi Amiriani, Alireza Norouzi, Farin Kamangar, Paolo Boffetta, Paul Brennan, Sanford M. Dawsey, Emily Vogtmann, Reza Malekzadeh and Arash Etemadi

Cancer Prev Res July 1 2021 14 (7) 709-718; DOI:10.1158/1940-6207.CAPR-20-0577

Poor oral health is associated with the risk of upper gastrointestinal cancers, and oral hygiene practices may help prevent these cancers.
Research Article

Independent and Joint Effects of Testosterone Replacement Therapy and Statins use on the Risk of Prostate Cancer Among White, Black, and Hispanic Men

David S. Lopez, Efstathia Polychronopoulou, Konstantinos K. Tsilidis, Mohit Khera, L. Joseph Su, Jay H. Fowke, M.K. Peek, Yong-Fang Kuo, Kyriakos Markides and Steven Canfield

Cancer Prev Res July 1 2021 14 (7) 719-728; DOI:10.1158/1940-6207.CAPR-21-0040

The study investigates a potential interaction between TTh and statin and its effect on incident and aggressive prostate cancer in men of different racial and ethnic backgrounds. These results suggest that among NHW and non-Hispanic Black men TTh plus statins reduced the odds of incident prostate cancer, high-grade and advance stage prostate cancer.
Research Article

The Influence of Vitamin D on Mammographic Density: Results from CALGB 70806 (Alliance) a Randomized Clinical Trial

Marie E. Wood, Heshan Liu, Elizabeth Storrick, David Zahrieh, H. Carisa Le-Petross, Sin-Ho Jung, Patricia Zekan, M. Margaret Kemeny, Jayne R. Charlamb, Lili X. Wang, Gary W. Unzeitig, Candace S. Johnson, Judy E. Garber, James R. Marshall and Isabelle Bedrosian

Cancer Prev Res July 1 2021 14 (7) 753-762; DOI:10.1158/1940-6207.CAPR-20-0581

Current therapies for breast cancer prevention only prevent estrogen receptor positive (ER+) disease and are underutilized due to toxicity and side effects. Vitamin D is a potential prevention therapy for both ER+ and ER− disease and is safe with few side effects.