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Research Article

Human Papillomavirus (HPV) 16/18 E6 Oncoprotein Expression in Infections with Single and Multiple Genotypes

Zeni Wu, Ting-Yuan Li, Mingyue Jiang, Lulu Yu, Jing Zhao, Hairui Wang, Xun Zhang, Wen Chen and Youlin Qiao
Zeni Wu
1Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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Ting-Yuan Li
1Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
2Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
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Mingyue Jiang
1Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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Lulu Yu
1Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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Jing Zhao
3School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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Hairui Wang
3School of Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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Xun Zhang
4Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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Wen Chen
1Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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  • For correspondence: chenwen@cicams.ac.cn qiaoy@cicams.ac.cn
Youlin Qiao
1Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
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  • ORCID record for Youlin Qiao
  • For correspondence: chenwen@cicams.ac.cn qiaoy@cicams.ac.cn
DOI: 10.1158/1940-6207.CAPR-18-0343 Published February 2019
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Article Figures & Data

Tables

  • Table 1.

    Sociodemographics and risk factors for study population (n, %)

    HPV16 (n = 621)HPV18 (n = 94)
    Total (n = 1,781)HPV Positive (n = 1,069)Single infection (n = 424)Multiple infection (n = 197)PSingle infection (n = 44)Multiple infection (n = 50)P
    Age, mean (range)48.2 (20–75)48.1 (20–75)47.1 (23–69)48.5 (27–75)49.5 (31–68)48.4 (25–67)
     <3056 (3.1)41 (3.8)17 (4.0)3 (1.5)0.1000 (0.0)2 (4.0)0.598
     30 ∼ 39249 (14.0)166 (15.5)71 (16.7)35 (17.8)5 (11.4)5 (10.0)
     40 ∼ 49674 (37.8)371 (34.7)159 (37.5)71 (36.0)15 (34.1)21 (42.0)
     50 ∼ 59569 (31.9)341 (31.9)135 (31.8)56 (28.4)19 (43.2)18 (36.0)
     ≥60233 (13.1)150 (14.0)42 (9.9)32 (16.2)5 (11.4)4 (8.0)
    Marital status
     Married/cohabitation1,764 (99.0)1,055 (98.7)416 (98.1)193 (98.0)0.90444 (100.0)50 (100.0)—–
     Divorced/widowed17 (1.0)14 (1.3)8 (1.9)4 (2.0)0 (0.0)0 (0.0)
    Smoking
     No1,737 (97.5)1,034 (96.7)402 (94.8)191 (97.0)0.20341 (93.2)50 (100.0)0.061
     Yes44 (2.5)35 (3.3)20 (4.7)4 (2.0)3 (6.8)0 (0.0)
    Drinking
     No1,430 (80.3)797 (74.6)330 (77.8)144 (71.6)0.23636 (81.8)40 (80.0)0.823
     Yes351 (19.7)272 (25.4)91 (21.5)54 (27.4)8 (18.2)10 (20.0)
    Gravidity
     ≤2627 (35.2)360 (33.7)134 (31.6)67 (34.0)0.55116 (36.4)14 (28.0)0.385
     ≥31,154 (64.8)709 (66.3)290 (68.4)130 (66.0)28 (63.6)36 (72.0)
    Parity
     ≤21,257 (70.6)725 (67.8)289 (68.2)136 (69.0)0.82731 (70.5)38 (76.0)0.544
     ≥3524 (29.4)344 (32.2)135 (31.8)61 (31.0)13 (29.5)12 (24.0)
    Oral contraceptive
     No1,773 (99.6)1,062 (99.5)422 (99.5)196 (99.5)0.95243 (97.7)50 (100.0)0.284
     Yes8 (0.4)5 (0.5)2 (0.5)1 (0.5)1 (2.3)0 (0.0)
    Menopause
     No1,131 (63.5)655 (61.3)273 (64.4)123 (62.4)0.63825 (56.8)31 (62.0)0.609
     Yes650 (36.5)414 (38.7)151 (35.6)74 (37.6)19 (43.2)19 (38.0)
  • Table 2.

    Distribution of histology and presence of E6 oncoprotein in HPV16/18 DNA–positive women (E6 protein/DNA, %)

    Normal/CIN1CIN2/3SCC/ADCTotal
    HPV16 (E6 protein/DNA, %)11/75 (14.7)85/166 (51.2)335/380 (88.2)431/621 (69.4)
     Single HPV16 infections6/42 (14.3)51/100 (51.0)260/282 (92.2)317/424 (74.8)
     Multiple HPV16 infections5/33 (15.2)34/66 (51.5)75/98 (76.5)114/197 (57.9)
     HPV16 & 180/5 (0.0)0/3 (0.0)12/20 (60.0)12/28 (42.9)
     HPV16 & 522/9 (22.2)7/14 (50.0)15/16 (93.8)24/39 (61.5)
     HPV16 & 59/56/660/10 (0.0)14/21 (66.7)17/23 (73.9)31/54 (57.4)
     HPV16 & 511/8 (12.5)4/5 (80.0)7/8 (87.5)12/21 (57.1)
     HPV16 & 33/582/11 (18.2)8/21 (38.1)22/28 (78.6)32/60 (53.3)
     HPV16 & 39/68/351/13 (7.7)9/15 (60.0)11/14 (78.6)21/42 (50.0)
     HPV16 & 310/6 (0.0)4/7 (57.1)9/13 (69.2)13/26 (50.0)
     HPV16 & 450/4 (0.0)0/2 (0.0)1/4 (25.0)1/10 (10.0)
    HPV18 (E6 protein/DNA, %)9/26 (34.6)3/6 (50.0)49/62 (79.0)61/94 (64.9)
     Single HPV18 infections3/9 (33.3)1/2(50.0)31/33 (93.9)35/44 (79.5)
     Multiple HPV18 infections6/17 (35.3)2/4 (50.0)18/29 (62.1)26/50 (52.0)
     HPV16 & 181/5 (20.0)1/3 (50.0)10/20 (50.0)12/28 (42.9)
     HPV18 & 522/2 (100.0)1/1 (100.0)1/3 (33.3)4/6 (66.7)
     HPV18 & 59/56/663/7 (42.9)0/0 (0.0)3/5 (60.0)6/12 (60.0)
     HPV18 & 312/3 (66.7)0/0 (0.0)1/2 (50.0)3/5 (60.0)
     HPV18 & 39/68/351/6 (16.7)0/0 (0.0)4/4 (100.0)5/10 (50.0)
     HPV18 & 450/0 (0.0)0/0 (0.0)1/2 (50.0)1/2 (50.0)
     HPV18 & 33/583/6 (50.0)0/0 (0.0)1/3 (33.3)4/9 (44.4)
     HPV18 & 510/4 (0.0)0/0 (0.0)1/2 (50.0)1/6 (16.7)
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Cancer Prevention Research: 12 (2)
February 2019
Volume 12, Issue 2
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Human Papillomavirus (HPV) 16/18 E6 Oncoprotein Expression in Infections with Single and Multiple Genotypes
Zeni Wu, Ting-Yuan Li, Mingyue Jiang, Lulu Yu, Jing Zhao, Hairui Wang, Xun Zhang, Wen Chen and Youlin Qiao
Cancer Prev Res February 1 2019 (12) (2) 95-102; DOI: 10.1158/1940-6207.CAPR-18-0343

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Human Papillomavirus (HPV) 16/18 E6 Oncoprotein Expression in Infections with Single and Multiple Genotypes
Zeni Wu, Ting-Yuan Li, Mingyue Jiang, Lulu Yu, Jing Zhao, Hairui Wang, Xun Zhang, Wen Chen and Youlin Qiao
Cancer Prev Res February 1 2019 (12) (2) 95-102; DOI: 10.1158/1940-6207.CAPR-18-0343
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