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Cancer Prevention Research

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Research Article

Association of Human Papillomavirus Genotype 16 Viral Variant and Viral Load with Cervical High-grade Intraepithelial Lesions

Ledicia Álvarez-Paredes, Miguel Santibañez, Antonio Galiana, Juan Carlos Rodríguez Díaz, Paula Parás-Bravo, Mª Encarnación Andrada-Becerra, María Montserrat Ruiz García, José María Rodríguez-Ingelmo, Joaquín Portilla-Sogorb and María Paz-Zulueta
Ledicia Álvarez-Paredes
Department of Microbiology and Parasitology, University Hospital of Burgos, Burgos, Spain.
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Miguel Santibañez
Department of Nursing, Nursing Research Group-IDIVAL, University of Cantabria, Cantabria, Spain.
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  • ORCID record for Miguel Santibañez
Antonio Galiana
Department of Microbiology, University General Hospital of Elche, Alicante, Spain.
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Juan Carlos Rodríguez Díaz
Department of Microbiology, University General Hospital of Alicante, Alicante, Spain.
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  • ORCID record for Juan Carlos Rodríguez Díaz
Paula Parás-Bravo
Department of Nursing, Nursing Research Group-IDIVAL, University of Cantabria, Cantabria, Spain.
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  • ORCID record for Paula Parás-Bravo
Mª Encarnación Andrada-Becerra
Department of Pathological Anatomy, University General Hospital of Elche, Alicante, Spain.
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María Montserrat Ruiz García
Department of Microbiology, University General Hospital of Elche, Alicante, Spain.
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José María Rodríguez-Ingelmo
Department of Gynecology, University General Hospital of Elche, Alicante, Spain.
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Joaquín Portilla-Sogorb
Department of Infectious Diseases, University Hospital of Alicante, Alicante, Spain.
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María Paz-Zulueta
Department of Nursing, University of Cantabria, Cantabria, Spain. IDIVAL, GI Derecho Sanitario y Bioetica, GRIDES, Cantabria, Spain.
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  • For correspondence: maria.paz@unican.es
DOI: 10.1158/1940-6207.CAPR-18-0397 Published August 2019
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Abstract

Human papillomavirus genotype 16 (HPV16) is by far the genotype most strongly associated with cervical cancer; viral variant and/or viral load of HPV16 could modulate this association. The objective was to determine the association between the viral variant and viral load of HPV16 and the presence of cervical high-grade lesions. This cross-sectional study included all women in whom HPV infection was found by cervical smear during routine gynecologic health checks. Women with single or multiple HPV16 infections (n = 176) were selected for viral variant and viral load analysis. Smear results were classified using the Bethesda system. HPV types were classified according to the International Agency for Research on Cancer. Odds ratios (OR) with their 95% confidence intervals (CI) were estimated by logistic regression, adjusted for age, immigrant status, and coinfection with other high-risk genotypes. No statistically significant associations were found regarding the detected viral variants. A viral load above the median (>1,367.79 copies/cell) was associated with a significant risk of high-grade epithelial lesion or carcinoma, after adjusting for age, immigrant status, coinfections, and viral variant: (adjusted OR 7.89; 95% CI: 2.75–22.68). This relationship showed a statistically significant dose–response pattern after categorizing by viral load tertiles: adjusted OR for a viral load greater than the third tertile was 17.23 (95% CI: 4.20–70.65), with adjusted linear Ptrend = 0.001. In patients infected with HPV16, viral load is associated with high-grade intraepithelial lesions or cervical carcinoma. This could be useful as prognostic biomarker of neoplastic progression and as screening for cervical cancer.

Footnotes

  • Note: Supplementary data for this article are available at Cancer Prevention Research Online (http://cancerprevres.aacrjournals.org/).

  • Cancer Prev Res 2019;12:547–56

  • Received October 14, 2018.
  • Revision received May 15, 2019.
  • Accepted June 11, 2019.
  • ©2019 American Association for Cancer Research.
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Cancer Prevention Research: 12 (8)
August 2019
Volume 12, Issue 8
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Association of Human Papillomavirus Genotype 16 Viral Variant and Viral Load with Cervical High-grade Intraepithelial Lesions
Ledicia Álvarez-Paredes, Miguel Santibañez, Antonio Galiana, Juan Carlos Rodríguez Díaz, Paula Parás-Bravo, Mª Encarnación Andrada-Becerra, María Montserrat Ruiz García, José María Rodríguez-Ingelmo, Joaquín Portilla-Sogorb and María Paz-Zulueta
Cancer Prev Res August 1 2019 (12) (8) 547-556; DOI: 10.1158/1940-6207.CAPR-18-0397

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Association of Human Papillomavirus Genotype 16 Viral Variant and Viral Load with Cervical High-grade Intraepithelial Lesions
Ledicia Álvarez-Paredes, Miguel Santibañez, Antonio Galiana, Juan Carlos Rodríguez Díaz, Paula Parás-Bravo, Mª Encarnación Andrada-Becerra, María Montserrat Ruiz García, José María Rodríguez-Ingelmo, Joaquín Portilla-Sogorb and María Paz-Zulueta
Cancer Prev Res August 1 2019 (12) (8) 547-556; DOI: 10.1158/1940-6207.CAPR-18-0397
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eISSN: 1940-6215
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