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Cancer Prevention Research
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How Does Obesity Drive Human Carcinogenesis? Challenges in Dissecting the Mechanisms of Adipose–Epithelial Signaling

Justin Colacino, Zora Djuric and Dean E. Brenner
Justin Colacino
1Department of Environmental Health Sciences and Department of Nutrition Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan.
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Zora Djuric
2Department of Family Medicine, University of Michigan Medical School, Ann Arbor, Michigan.
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Dean E. Brenner
3Division of Hematology-Oncology, Department of Internal Medicine and Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.
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  • For correspondence: dbrenner@med.umich.edu
DOI: 10.1158/1940-6207.CAPR-20-0367 Published October 2020
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Abstract

Obesity is the second leading environmental association with cancer risk; yet, the mechanisms by which obesity drives carcinogenesis are poorly understood. The paper published in this issue of Cancer Prevention Research by Holowatyj and colleagues explores the mechanisms of human visceral adipose–epithelial signaling using samples collected at surgery in patients with invasive colorectal cancer. They identify pathway intermediates potentially involved in the regulation of fibrosis, inflammation, glycosis, and epithelial–mesenchymal transition in neoplastic tissue. ‘Omics-based profiling of perioperative human biosamples has potential for inherent biases (preoperative and intraoperative drug therapies, hydration, dynamics, inflammatory response to surgical intervention) and appropriate control samples are difficult to identify and collect. Solutions to this dilemma may include strategies to identify patients undergoing similar surgical procedures but who are without neoplasms, for example, patients with gynecologic problems, abdominal exploration for suspected appendicitis, symptoms or resection of gall stone disease or undergoing bariatric surgery. As the field continues to grow, studies incorporating robust statistical analyses, validation of findings in diverse cohorts, and public data sharing will be essential to identify biological pathways linking obesity and carcinogenesis to be further interrogated using focused, hypothesis-driven approaches.

See related article by Holowatyj et al., p. 817

Footnotes

  • Cancer Prev Res 2020;13:803–6

  • Received July 8, 2020.
  • Revision received August 3, 2020.
  • Accepted August 5, 2020.
  • Published first August 24, 2020.
  • ©2020 American Association for Cancer Research.
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Cancer Prevention Research: 13 (10)
October 2020
Volume 13, Issue 10
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How Does Obesity Drive Human Carcinogenesis? Challenges in Dissecting the Mechanisms of Adipose–Epithelial Signaling
Justin Colacino, Zora Djuric and Dean E. Brenner
Cancer Prev Res October 1 2020 (13) (10) 803-806; DOI: 10.1158/1940-6207.CAPR-20-0367

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How Does Obesity Drive Human Carcinogenesis? Challenges in Dissecting the Mechanisms of Adipose–Epithelial Signaling
Justin Colacino, Zora Djuric and Dean E. Brenner
Cancer Prev Res October 1 2020 (13) (10) 803-806; DOI: 10.1158/1940-6207.CAPR-20-0367
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Cancer Prevention Research
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