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Cancer Prevention Research
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Research Article

The Impact of One-week Dietary Supplementation with Kava on Biomarkers of Tobacco Use and Nitrosamine-based Carcinogenesis Risk among Active Smokers

Yi Wang, Sreekanth C. Narayanapillai, Katelyn M. Tessier, Lori G. Strayer, Pramod Upadhyaya, Qi Hu, Rick Kingston, Ramzi G. Salloum, Junxuan Lu, Stephen S. Hecht, Dorothy K. Hatsukami, Naomi Fujioka and Chengguo Xing
Yi Wang
1Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida.
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Sreekanth C. Narayanapillai
1Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida.
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Katelyn M. Tessier
2Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
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Lori G. Strayer
2Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
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Pramod Upadhyaya
2Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
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Qi Hu
1Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida.
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Rick Kingston
3College of Pharmacy, University of Minnesota, Minneapolis, Minnesota.
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Ramzi G. Salloum
4Department of Health Outcome & Biomedical Informatics, College of Medicine, University of Florida, Gainesville, Florida.
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Junxuan Lu
5Department of Pharmacology and Cancer Institute, Penn State, Hershey, Pennsylvania.
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Stephen S. Hecht
2Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
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Dorothy K. Hatsukami
2Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
6Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota.
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Naomi Fujioka
2Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
7Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.
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  • For correspondence: chengguoxing@cop.ufl.edu fujio002@umn.edu
Chengguo Xing
1Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida.
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  • For correspondence: chengguoxing@cop.ufl.edu fujio002@umn.edu
DOI: 10.1158/1940-6207.CAPR-19-0501 Published May 2020
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Abstract

Tobacco smoking is the primary risk factor for lung cancer, driven by the addictive nature of nicotine and the indisputable carcinogenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) as well as other compounds. The integration of lung cancer chemoprevention with smoking cessation is one potential approach to reduce this risk and mitigate lung cancer mortality. Experimental data from our group suggest that kava, commonly consumed in the South Pacific Islands as a beverage to promote relaxation, may reduce lung cancer risk by enhancing NNK detoxification and reducing NNK-derived DNA damage. Building upon these observations, we conducted a pilot clinical trial to evaluate the effects of a 7-day course of kava on NNK metabolism in active smokers. The primary objective was to compare urinary total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL plus its glucuronides, major metabolites of NNK) before and after kava administration as an indicator of NNK detoxification. Secondary objectives included determining kava's safety, its effects on DNA damage, tobacco use, and cortisol (a biomarker of stress). Kava increased urinary excretion of total NNAL and reduced urinary 3-methyladenine in participants, suggestive of its ability to reduce the carcinogenicity of NNK. Kava also reduced urinary total nicotine equivalents, indicative of its potential to facilitate tobacco cessation. Plasma cortisol and urinary total cortisol equivalents were reduced upon kava use, which may contribute to reductions in tobacco use. These results demonstrate the potential of kava intake to reduce lung cancer risk among smokers.

Footnotes

  • Note: Supplementary data for this article are available at Cancer Prevention Research Online (http://cancerprevres.aacrjournals.org/).

  • Cancer Prev Res 2020;13:483–92

  • Received November 4, 2019.
  • Revision received January 16, 2020.
  • Accepted February 20, 2020.
  • Published first February 26, 2020.
  • ©2020 American Association for Cancer Research.
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Cancer Prevention Research: 13 (5)
May 2020
Volume 13, Issue 5
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The Impact of One-week Dietary Supplementation with Kava on Biomarkers of Tobacco Use and Nitrosamine-based Carcinogenesis Risk among Active Smokers
Yi Wang, Sreekanth C. Narayanapillai, Katelyn M. Tessier, Lori G. Strayer, Pramod Upadhyaya, Qi Hu, Rick Kingston, Ramzi G. Salloum, Junxuan Lu, Stephen S. Hecht, Dorothy K. Hatsukami, Naomi Fujioka and Chengguo Xing
Cancer Prev Res May 1 2020 (13) (5) 483-492; DOI: 10.1158/1940-6207.CAPR-19-0501

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The Impact of One-week Dietary Supplementation with Kava on Biomarkers of Tobacco Use and Nitrosamine-based Carcinogenesis Risk among Active Smokers
Yi Wang, Sreekanth C. Narayanapillai, Katelyn M. Tessier, Lori G. Strayer, Pramod Upadhyaya, Qi Hu, Rick Kingston, Ramzi G. Salloum, Junxuan Lu, Stephen S. Hecht, Dorothy K. Hatsukami, Naomi Fujioka and Chengguo Xing
Cancer Prev Res May 1 2020 (13) (5) 483-492; DOI: 10.1158/1940-6207.CAPR-19-0501
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