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Cancer Prevention Research
Cancer Prevention Research
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Research Article

Inhibition of miR-21 Regulates Mutant KRAS Effector Pathways and Intercepts Pancreatic Ductal Adenocarcinoma Development

Nina J. Chu, Robert A. Anders, Elana J. Fertig, Minwei Cao, Alexander C. Hopkins, Bridget P. Keenan, Aleksandra Popovic, Todd D. Armstrong, Elizabeth M. Jaffee and Jacquelyn W. Zimmerman
Nina J. Chu
1Department of Oncology, Skip Viragh Center for Pancreas Cancer, Bloomberg Kimmel Institute for Cancer Immunotherapy, and the Sidney Kimmel Cancer Center at Johns Hopkins University School of Medicine, Baltimore, Maryland.
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Robert A. Anders
1Department of Oncology, Skip Viragh Center for Pancreas Cancer, Bloomberg Kimmel Institute for Cancer Immunotherapy, and the Sidney Kimmel Cancer Center at Johns Hopkins University School of Medicine, Baltimore, Maryland.
2Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.
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Elana J. Fertig
1Department of Oncology, Skip Viragh Center for Pancreas Cancer, Bloomberg Kimmel Institute for Cancer Immunotherapy, and the Sidney Kimmel Cancer Center at Johns Hopkins University School of Medicine, Baltimore, Maryland.
3Department of Applied Mathematics and Statistics, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland.
4Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland.
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Minwei Cao
1Department of Oncology, Skip Viragh Center for Pancreas Cancer, Bloomberg Kimmel Institute for Cancer Immunotherapy, and the Sidney Kimmel Cancer Center at Johns Hopkins University School of Medicine, Baltimore, Maryland.
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Alexander C. Hopkins
1Department of Oncology, Skip Viragh Center for Pancreas Cancer, Bloomberg Kimmel Institute for Cancer Immunotherapy, and the Sidney Kimmel Cancer Center at Johns Hopkins University School of Medicine, Baltimore, Maryland.
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Bridget P. Keenan
1Department of Oncology, Skip Viragh Center for Pancreas Cancer, Bloomberg Kimmel Institute for Cancer Immunotherapy, and the Sidney Kimmel Cancer Center at Johns Hopkins University School of Medicine, Baltimore, Maryland.
5Division of Hematology/Oncology, Department of Medicine, University of California San Francisco, San Francisco, California.
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  • ORCID record for Bridget P. Keenan
Aleksandra Popovic
1Department of Oncology, Skip Viragh Center for Pancreas Cancer, Bloomberg Kimmel Institute for Cancer Immunotherapy, and the Sidney Kimmel Cancer Center at Johns Hopkins University School of Medicine, Baltimore, Maryland.
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  • ORCID record for Aleksandra Popovic
Todd D. Armstrong
1Department of Oncology, Skip Viragh Center for Pancreas Cancer, Bloomberg Kimmel Institute for Cancer Immunotherapy, and the Sidney Kimmel Cancer Center at Johns Hopkins University School of Medicine, Baltimore, Maryland.
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Elizabeth M. Jaffee
1Department of Oncology, Skip Viragh Center for Pancreas Cancer, Bloomberg Kimmel Institute for Cancer Immunotherapy, and the Sidney Kimmel Cancer Center at Johns Hopkins University School of Medicine, Baltimore, Maryland.
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  • ORCID record for Elizabeth M. Jaffee
Jacquelyn W. Zimmerman
1Department of Oncology, Skip Viragh Center for Pancreas Cancer, Bloomberg Kimmel Institute for Cancer Immunotherapy, and the Sidney Kimmel Cancer Center at Johns Hopkins University School of Medicine, Baltimore, Maryland.
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  • For correspondence: jzimme27@jhmi.edu
DOI: 10.1158/1940-6207.CAPR-20-0053 Published July 2020
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Cancer Prevention Research: 13 (7)
July 2020
Volume 13, Issue 7
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Inhibition of miR-21 Regulates Mutant KRAS Effector Pathways and Intercepts Pancreatic Ductal Adenocarcinoma Development
Nina J. Chu, Robert A. Anders, Elana J. Fertig, Minwei Cao, Alexander C. Hopkins, Bridget P. Keenan, Aleksandra Popovic, Todd D. Armstrong, Elizabeth M. Jaffee and Jacquelyn W. Zimmerman
Cancer Prev Res July 1 2020 (13) (7) 569-582; DOI: 10.1158/1940-6207.CAPR-20-0053

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Inhibition of miR-21 Regulates Mutant KRAS Effector Pathways and Intercepts Pancreatic Ductal Adenocarcinoma Development
Nina J. Chu, Robert A. Anders, Elana J. Fertig, Minwei Cao, Alexander C. Hopkins, Bridget P. Keenan, Aleksandra Popovic, Todd D. Armstrong, Elizabeth M. Jaffee and Jacquelyn W. Zimmerman
Cancer Prev Res July 1 2020 (13) (7) 569-582; DOI: 10.1158/1940-6207.CAPR-20-0053
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Cancer Prevention Research
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