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Cancer Prevention Research
Cancer Prevention Research
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Table of Contents

Review

  • Review
    Mitochondria as a Novel Target for Cancer Chemoprevention: Emergence of Mitochondrial-targeting Agents
    Mofei Huang, Charles R. Myers, Yian Wang and Ming You
    Cancer Prev Res March 1 2021 14 (3) 285-306; DOI:10.1158/1940-6207.CAPR-20-0425

Research Brief

  • Research Brief
    An Improved Murine Premalignant Squamous Cell Model: Tobacco Smoke Exposure Augments NTCU-Induced Murine Airway Dysplasia
    Lori D. Dwyer-Nield, Debbie G. McArthur, Meredith A. Tennis, Daniel T. Merrick and Robert L. Keith
    Cancer Prev Res March 1 2021 14 (3) 307-312; DOI:10.1158/1940-6207.CAPR-20-0332

Research Articles

  • Research Article
    Targeting of CD40 and PD-L1 Pathways Inhibits Progression of Oral Premalignant Lesions in a Carcinogen-induced Model of Oral Squamous Cell Carcinoma
    Jose A. Monteiro de Oliveira Novaes, Taghreed Hirz, Irene Guijarro, Monique Nilsson, Marlese A. Pisegna, Alissa Poteete, Hampartsoum B. Barsoumian, Jared J. Fradette, Limo N. Chen, Don L. Gibbons, Xiangjun Tian, Jing Wang, Jeffrey N. Myers, Mark J. McArthur, Diana Bell, William N. William Jr and John V. Heymach
    Cancer Prev Res March 1 2021 14 (3) 313-324; DOI:10.1158/1940-6207.CAPR-20-0418

    PD-1/PD-L1 pathway blockade, as well as activation of the CD40 pathway, were able to prevent OPL progression into invasive OSCC in a murine model. A distinct pattern of immune modulation was observed when either the CD40 or the PD-1/PD-L1 pathways were targeted.

  • Research Article
    Optimization of Erlotinib Plus Sulindac Dosing Regimens for Intestinal Cancer Prevention in an Apc-Mutant Model of Familial Adenomatous Polyposis (FAP)
    Ahmet M. Ulusan, Praveen Rajendran, Wan Mohaiza Dashwood, Omer F. Yavuz, Sabeeta Kapoor, Trace A. Gustafson, Michelle I. Savage, Powel H. Brown, Shizuko Sei, Altaf Mohammed, Eduardo Vilar and Roderick H. Dashwood
    Cancer Prev Res March 1 2021 14 (3) 325-336; DOI:10.1158/1940-6207.CAPR-20-0262

    This investigation concludes that switching from continuous to once-per-week erlotinib, given at one-quarter of the current therapeutic dose, will exert good efficacy with standard-of-care sulindac against adenomatous polyps in the colon and small intestine, with clinical relevance for patients with FAP before or after colectomy.

  • Research Article
    Diet-Associated Inflammation Modulates Inflammation and WNT Signaling in the Rectal Mucosa, and the Response to Supplementation with Dietary Fiber
    Fiona C. Malcomson, Naomi D. Willis, Iain McCallum, Long Xie, Nitin Shivappa, Michael D. Wirth, James R. Hébert, Betul Kocaadam-Bozkurt, Aycil Özturan-Sirin, Seamus B. Kelly, D. Michael Bradburn, Nigel J. Belshaw, Ian T. Johnson and John C. Mathers
    Cancer Prev Res March 1 2021 14 (3) 337-346; DOI:10.1158/1940-6207.CAPR-20-0335

    Our finding that more inflammatory dietary components may impact large bowel health through effects on awell-recognized pathway involved in cancer development will strengthen the evidence base for dietary advice to help prevent bowel cancer.

  • Research Article
    Association of IgG Glycosylation and Esophageal Precancerosis Beyond Inflammation
    Zhiyuan Wu, Huiying Pan, Di Liu, Di Zhou, Lixin Tao, Jie Zhang, Xiaonan Wang, Youxin Wang, Wei Wang and Xiuhua Guo
    Cancer Prev Res March 1 2021 14 (3) 347-354; DOI:10.1158/1940-6207.CAPR-20-0489

    IgG glycosylation profile is associated with esophageal precancerosis and specific IgG glycans involves in the early stage of esophageal cancer, which is independent of inflammation.

  • Research Article | AuthorChoice
    Clinical Evaluation of DNA Ploidy for the Triage of HPV-Positive Chinese Women During Cervical Cancer Screening
    Wei Cang, Qing Li, Liying Gu, Zubei Hong, Yuan Hu, Wen Di and Lihua Qiu
    Cancer Prev Res March 1 2021 14 (3) 355-362; DOI:10.1158/1940-6207.CAPR-20-0229

    Results from this study indicate that DNA ploidy analysis has good performance in early detection of high-grade precancerous and cancerous lesions of the cervix. This strategy could be used in the triage of HPV-positive women in cervical cancer screening.

  • Research Article
    Effect of Sequential Rounds of Cervical Cancer Screening on Management of HPV-positive Women: A 15-year Population-based Cohort Study from China
    Xiao-Qian Xu, Remila Rezhake, Shang-Ying Hu, Feng Chen, Xun Zhang, Qin-Jing Pan, Wen-Hua Zhang, Jun-Fei Ma, You-Lin Qiao, Fang-Hui Zhao and Margaret Cruickshank
    Cancer Prev Res March 1 2021 14 (3) 363-372; DOI:10.1158/1940-6207.CAPR-20-0456

    The study highlights the sustained effectiveness of mainstream HPV triage methods, such as cytology and genotyping, after sequential rounds of cervical screening. It also suggests that use of HPV persistence across rounds can improve management of HPV-positive women in cervical cancer screening.

  • Research Article
    Screening for Pancreatic Ductal Adenocarcinoma: Are We Asking the Impossible?
    Katharine E. Caldwell, Alexander P. Conway and Chet W. Hammill
    Cancer Prev Res March 1 2021 14 (3) 373-382; DOI:10.1158/1940-6207.CAPR-20-0426

    For patients with pancreatic cancer, early stage detection offers the greatest survival benefit. However, the incidence of pancreatic cancer and associated mortality of pancreatic resections make development of a screening test a difficult, if not impossible, challenge.

  • Research Article
    Baseline Oral Microbiome and All-cancer Incidence in a Cohort of Nonsmoking Mexican American Women
    Xiaotao Zhang, Kristi L. Hoffman, Peng Wei, Kplola Y. Elhor Gbito, Reji Joseph, Fangyu Li, Paul Scheet, Shine Chang, Joseph F. Petrosino and Carrie R. Daniel
    Cancer Prev Res March 1 2021 14 (3) 383-392; DOI:10.1158/1940-6207.CAPR-20-0405

    Mexican American women suffer a disproportionate burden of chronic health conditions that increase cancer risk. Few investigations of the microbiome, a key determinant of host health, have been conducted among this group. Oral microbiota profiles may provide early and accessible cancer biomarker data on invasive bacteria or community disruptions.

  • Research Article
    Effects of Supplemental Calcium and Vitamin D on Circulating Biomarkers of Gut Barrier Function in Patients with Colon Adenoma: A Randomized Clinical Trial
    Kelly Vermandere, Roberd M. Bostick, Hao Q. Tran, Andrew T. Gewirtz, Elizabeth L. Barry, Robin E. Rutherford, March E. Seabrook and Veronika Fedirko
    Cancer Prev Res March 1 2021 14 (3) 393-402; DOI:10.1158/1940-6207.CAPR-20-0461

    Calcium and vitamin D may be involved in regulating and maintaining the integrity of the intestinal mucosal barrier, the dysfunction of which results in exposure of the host to luminal bacteria, endotoxins, and antigens leading to potentially cancer-promoting endotoxemia and chronic colon inflammation. While our results suggest that daily supplementation with these chemopreventive agents does not modify circulating concentrations of gut permeability biomarkers, they support continued investigation of other potential modifiable factors, such as diet and excess adiposity, that could alter gut barrier function, to inform the development of treatable biomarkers of risk for colorectal neoplasms and effective colon cancer preventive strategies.

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Cancer Prevention Research: 14 (3)
March 2021
Volume 14, Issue 3
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Cancer Prevention Research
eISSN: 1940-6215
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