Table of Contents

Research Articles

• Research Article

  Targeting of CD40 and PD-L1 Pathways Inhibits Progression of Oral Premalignant Lesions in a Carcinogen-induced Model of Oral Squamous Cell Carcinoma

  Jose A. Monteiro de Oliveira Novaes, Taghreed Hirz, Irene Guijarro, Monique Nilsson, Marlese A. Pisegna, Alissa Poteete, Hampartsoum B. Barsoumian, Jared J. Fradette, Limo N. Chen, Don L. Gibbons, Xiangjun Tian, Jing Wang, Jeffrey N. Myers, Mark J. McArthur, Diana Bell, William N. William Jr and John V. Heymach

  Cancer Prev Res March 1 2021 14 (3) 313-324; DOI:10.1158/1940-6207.CAPR-20-0418

  
  

  PD-1/PD-L1 pathway blockade, as well as activation of the CD40 pathway, were able to prevent OPL progression into invasive OSCC in a murine model. A distinct pattern of immune modulation was observed when either the CD40 or the PD-1/PD-L1 pathways were targeted.
• Research Article

  Optimization of Erlotinib Plus Sulindac Dosing Regimens for Intestinal Cancer Prevention in an Apc-Mutant Model of Familial Adenomatous Polyposis (FAP)

  Ahmet M. Ulusan, Praveen Rajendran, Wan Mohaiza Dashwood, Omer F. Yavuz, Sabeeta Kapoor, Trace A. Gustafson, Michelle I. Savage, Powel H. Brown, Shizuko Sei, Altaf Mohammed, Eduardo Vilar and Roderick H. Dashwood

  Cancer Prev Res March 1 2021 14 (3) 325-336; DOI:10.1158/1940-6207.CAPR-20-0262

  
  

  This investigation concludes that switching from continuous to once-per-week erlotinib, given at one-quarter of the current therapeutic dose, will exert good efficacy with standard-of-care sulindac against adenomatous polyps in the colon and small intestine, with clinical relevance for patients with FAP before or after colectomy.
• Research Article

  Diet-Associated Inflammation Modulates Inflammation and WNT Signaling in the Rectal Mucosa, and the Response to Supplementation with Dietary Fiber

  Fiona C. Malcomson, Naomi D. Willis, Iain McCallum, Long Xie, Nitin Shivappa, Michael D. Wirth, James R. Hébert, Betul Kocaadam-Bozkurt, Aycil Özturan-Sirin, Seamus B. Kelly, D. Michael Bradburn, Nigel J. Belshaw, Ian T. Johnson and John C. Mathers

  Cancer Prev Res March 1 2021 14 (3) 337-346; DOI:10.1158/1940-6207.CAPR-20-0335

  
  

  Our finding that more inflammatory dietary components may impact large bowel health through effects on awell-recognized pathway involved in cancer development will strengthen the evidence base for dietary advice to help prevent bowel cancer.
• Research Article

  Association of IgG Glycosylation and Esophageal Precancerosis Beyond Inflammation

  Zhiyuan Wu, Huiying Pan, Di Liu, Di Zhou, Lixin Tao, Jie Zhang, Xiaonan Wang, Youxin Wang, Wei Wang and Xiuhua Guo

  Cancer Prev Res March 1 2021 14 (3) 347-354; DOI:10.1158/1940-6207.CAPR-20-0489

  
  

  IgG glycosylation profile is associated with esophageal precancerosis and specific IgG glycans involves in the early stage of esophageal cancer, which is independent of inflammation.
• Research Article | AuthorChoice

  Clinical Evaluation of DNA Ploidy for the Triage of HPV-Positive Chinese Women During Cervical Cancer Screening

  Wei Cang, Qing Li, Liying Gu, Zubei Hong, Yuan Hu, Wen Di and Lihua Qiu

  Cancer Prev Res March 1 2021 14 (3) 355-362; DOI:10.1158/1940-6207.CAPR-20-0229

  
  

  Results from this study indicate that DNA ploidy analysis has good performance in early detection of high-grade precancerous and cancerous lesions of the cervix. This strategy could be used in the triage of HPV-positive women in cervical cancer screening.
• Research Article

  Effect of Sequential Rounds of Cervical Cancer Screening on Management of HPV-positive Women: A 15-year Population-based Cohort Study from China

  Xiao-Qian Xu, Remila Rezhake, Shang-Ying Hu, Feng Chen, Xun Zhang, Qin-Jing Pan, Wen-Hua Zhang, Jun-Fei Ma, You-Lin Qiao, Fang-Hui Zhao and Margaret Cruickshank

  Cancer Prev Res March 1 2021 14 (3) 363-372; DOI:10.1158/1940-6207.CAPR-20-0456

  
  

  The study highlights the sustained effectiveness of mainstream HPV triage methods, such as cytology and genotyping, after sequential rounds of cervical screening. It also suggests that use of HPV persistence across rounds can improve management of HPV-positive women in cervical cancer screening.
• Research Article

  Screening for Pancreatic Ductal Adenocarcinoma: Are We Asking the Impossible?

  Katharine E. Caldwell, Alexander P. Conway and Chet W. Hammill

  Cancer Prev Res March 1 2021 14 (3) 373-382; DOI:10.1158/1940-6207.CAPR-20-0426

  
  

  For patients with pancreatic cancer, early stage detection offers the greatest survival benefit. However, the incidence of pancreatic cancer and associated mortality of pancreatic resections make development of a screening test a difficult, if not impossible, challenge.
• Research Article

  Baseline Oral Microbiome and All-cancer Incidence in a Cohort of Nonsmoking Mexican American Women

  Xiaotao Zhang, Kristi L. Hoffman, Peng Wei, Kplola Y. Elhor Gbito, Reji Joseph, Fangyu Li, Paul Scheet, Shine Chang, Joseph F. Petrosino and Carrie R. Daniel

  Cancer Prev Res March 1 2021 14 (3) 383-392; DOI:10.1158/1940-6207.CAPR-20-0405

  
  

  Mexican American women suffer a disproportionate burden of chronic health conditions that increase cancer risk. Few investigations of the microbiome, a key determinant of host health, have been conducted among this group. Oral microbiota profiles may provide early and accessible cancer biomarker data on invasive bacteria or community disruptions.
• Research Article

  Effects of Supplemental Calcium and Vitamin D on Circulating Biomarkers of Gut Barrier Function in Patients with Colon Adenoma: A Randomized Clinical Trial

  Kelly Vermandere, Roberd M. Bostick, Hao Q. Tran, Andrew T. Gewirtz, Elizabeth L. Barry, Robin E. Rutherford, March E. Seabrook and Veronika Fedirko

  Cancer Prev Res March 1 2021 14 (3) 393-402; DOI:10.1158/1940-6207.CAPR-20-0461

  
  

  Calcium and vitamin D may be involved in regulating and maintaining the integrity of the intestinal mucosal barrier, the dysfunction of which results in exposure of the host to luminal bacteria, endotoxins, and antigens leading to potentially cancer-promoting endotoxemia and chronic colon inflammation. While our results suggest that daily supplementation with these chemopreventive agents does not modify circulating concentrations of gut permeability biomarkers, they support continued investigation of other potential modifiable factors, such as diet and excess adiposity, that could alter gut barrier function, to inform the development of treatable biomarkers of risk for colorectal neoplasms and effective colon cancer preventive strategies.