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Cancer Prevention Research
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Research Article

Association of IgG Glycosylation and Esophageal Precancerosis Beyond Inflammation

Zhiyuan Wu, Huiying Pan, Di Liu, Di Zhou, Lixin Tao, Jie Zhang, Xiaonan Wang, Youxin Wang, Wei Wang and Xiuhua Guo
Zhiyuan Wu
1Beijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, P.R. China.
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Huiying Pan
1Beijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, P.R. China.
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Di Liu
1Beijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, P.R. China.
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Di Zhou
1Beijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, P.R. China.
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Lixin Tao
1Beijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, P.R. China.
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Jie Zhang
1Beijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, P.R. China.
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Xiaonan Wang
1Beijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, P.R. China.
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Youxin Wang
1Beijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, P.R. China.
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Wei Wang
1Beijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, P.R. China.
2Department of Public Health, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.
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Xiuhua Guo
1Beijing Municipal Key Laboratory of Clinical Epidemiology, Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, P.R. China.
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  • For correspondence: statistics_5@163.com
DOI: 10.1158/1940-6207.CAPR-20-0489 Published March 2021
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Abstract

This study aimed to investigate the association of IgG glycosylation and esophageal precancerosis for squamous cell carcinoma and determine its role in inflammation. Primary glycans selected by the least absolute shrinkage and selection operator (LASSO) algorithm were validated using univariate and multivariate logistics models plus restricted cubic spline functions. In total, 24 direct glycans and 27 derived traits were detected, among which four glycans and three derived traits were primarily selected. Then, GP5 (adjusted OR: 0.805), GP17 (adjusted OR: 1.305), G12n (adjusted OR: 1.271), Gal_1 (adjusted OR: 0.776) and Fuc (adjusted OR: 0.737) were validated and significantly associated with esophageal precancerosis. In addition, there was a consistent positive association in GP17 and G12n and a negative association in GP5, Gal_1, and Fuc by restricted cubic spline function. Compared with esophageal inflammation, GP17, G12n, and Fuc were still independently associated with precancerosis. In brief, the IgG glycosylation profile was independently associated with esophageal precancerosis beyond inflammation, which could be an early biomarker for esophageal cancer.

Prevention Relevance: IgG glycosylation profile is associated with esophageal precancerosis and specific IgG glycans involves in the early stage of esophageal cancer, which is independent of inflammation.

Footnotes

  • Note: Supplementary data for this article are available at Cancer Prevention Research Online (http://cancerprevres.aacrjournals.org/).

  • Cancer Prev Res 2021;14:347–54

  • Received September 17, 2020.
  • Revision received October 26, 2020.
  • Accepted December 4, 2020.
  • Published first December 10, 2020.
  • ©2020 American Association for Cancer Research.
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Cancer Prevention Research: 14 (3)
March 2021
Volume 14, Issue 3
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Association of IgG Glycosylation and Esophageal Precancerosis Beyond Inflammation
Zhiyuan Wu, Huiying Pan, Di Liu, Di Zhou, Lixin Tao, Jie Zhang, Xiaonan Wang, Youxin Wang, Wei Wang and Xiuhua Guo
Cancer Prev Res March 1 2021 (14) (3) 347-354; DOI: 10.1158/1940-6207.CAPR-20-0489

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Association of IgG Glycosylation and Esophageal Precancerosis Beyond Inflammation
Zhiyuan Wu, Huiying Pan, Di Liu, Di Zhou, Lixin Tao, Jie Zhang, Xiaonan Wang, Youxin Wang, Wei Wang and Xiuhua Guo
Cancer Prev Res March 1 2021 (14) (3) 347-354; DOI: 10.1158/1940-6207.CAPR-20-0489
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