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Cancer Prevention Research
Cancer Prevention Research
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Table of Contents

Review

  • Review
    Diet-Dependent Metabolic Regulation of DNA Double-Strand Break Repair in Cancer: More Choices on the Menu
    Anna de Polo and David P. Labbé
    Cancer Prev Res April 1 2021 14 (4) 403-414; DOI:10.1158/1940-6207.CAPR-20-0470

Research Brief

  • Research Brief
    Catch-up HPV Vaccination and Subsequent Uptake of Papanicolaou Testing in A State-mandated Health System
    Gabriel Chodick, Amy E. Leader and Sharon Larson
    Cancer Prev Res April 1 2021 14 (4) 415-420; DOI:10.1158/1940-6207.CAPR-20-0570

    We found that catch-up HPV vaccination was associated with increased attention to long-term cervical screening attendance. Whereas, those who are not vaccinated and unprotected from HPV, are more likely to abstain from secondary prevention screening tests too and further increase their cervical cancer risk.

Research Articles

  • Research Article
    The Role of Forkhead Box Q1 Transcription Factor in Anticancer Effects of Withaferin A in Breast Cancer
    Su-Hyeong Kim, Krishna B. Singh, Eun-Ryeong Hahm and Shivendra V. Singh
    Cancer Prev Res April 1 2021 14 (4) 421-432; DOI:10.1158/1940-6207.CAPR-20-0590

    Withaferin A (WA) is highly effective in reducing burden and/or incidence of breast cancer in various preclinical models. However, the mechanism underlying breast cancer prevention byWA is not fully understood. This study shows a role for FoxQ1 in antitumor response to WA.

  • Research Article | AuthorChoice
    Germline Pathogenic Variants in the Ataxia Telangiectasia Mutated (ATM) Gene are Associated with High and Moderate Risks for Multiple Cancers
    Michael J. Hall, Ryan Bernhisel, Elisha Hughes, Katie Larson, Eric T. Rosenthal, Nanda A. Singh, Johnathan M. Lancaster and Allison W. Kurian
    Cancer Prev Res April 1 2021 14 (4) 433-440; DOI:10.1158/1940-6207.CAPR-20-0448

    This study estimated risks for multiple cancers associated with ATM pathogenic variants independent of family history. These results indicate that some common variants may be associated with higher breast cancer risks than previously appreciated and increased screening for prostate and gastric cancer may be warranted for carriers of ATM pathogenic variants.

  • Research Article
    Functional Common and Rare ERBB2 Germline Variants Cooperate in Familial and Sporadic Cancer Susceptibility
    Riyue Bao, Anita Ng, Mark Sasaki, Myvizhi Esai Selvan, Alyna Katti, Hyesan Lee, Lei Huang, Andrew D. Skol, Cinzia Lavarino, Hector Salvador, Robert J. Klein, Zeynep H. Gümüş, Jaume Mora and Kenan Onel
    Cancer Prev Res April 1 2021 14 (4) 441-454; DOI:10.1158/1940-6207.CAPR-20-0094

    By performing whole-exome sequencing on germline DNA from multiple cancer-affected individuals belonging to a family in which multiple cancer types track across three generations, we identified and then characterized functional common and rare variation in ERBB2 associated with both sporadic and familial cancer. Our results suggest that heritable variation activating ERBB2 signaling is associated with risk for multiple cancer types, with increases in signaling correlated with increases in risk, and modified by ancestry or family history.

  • Research Article
    Cost Effectiveness of Whole Population BRCA Genetic Screening for Cancer Prevention in Israel
    Nadav Michaan, Moshe Leshno, Tamar Safra, Amir Sonnenblick, Ido Laskov and Dan Grisaru
    Cancer Prev Res April 1 2021 14 (4) 455-462; DOI:10.1158/1940-6207.CAPR-20-0411

    Whole population BRCA mutation screening in Israel is cost effective across a wide prevalence rate and should be offered as part of general health screening strategies by national medical insurance providers for cancer prevention.

  • Research Article
    Obesity is Associated with Shorter Telomere Length in Prostate Stromal Cells in Men with Aggressive Prostate Cancer
    Corinne E. Joshu, Christopher M. Heaphy, John R. Barber, Jiayun Lu, Reza Zarinshenas, Christine Davis, Misop Han, Tamara L. Lotan, Karen S. Sfanos, Angelo M. De Marzo, Alan K. Meeker and Elizabeth A. Platz
    Cancer Prev Res April 1 2021 14 (4) 463-470; DOI:10.1158/1940-6207.CAPR-20-0250

    This study investigates a potential mechanism underlying the association between obesity and prostate cancer death. Among men with aggressive prostate cancer, obesity was associated with shorter telomeres prostate cancer associated stromal cells, and shorter CAS telomeres have been associated with an increased risk of prostate cancer death.

  • Research Article
    A Retrospective Chart Review of Children in Neurocutaneous Clinic Who May Benefit from Further Evaluation Beyond Neurofibromatosis Type I
    Stephanie R. Hicks, Amanda K. Cozart, Gary A. Bellus and Kami W. Schneider
    Cancer Prev Res April 1 2021 14 (4) 471-478; DOI:10.1158/1940-6207.CAPR-20-0373

    This study suggests that at-risk population with a suspected NF1 diagnosis may benefit from further evaluation. Correct diagnosis of constitutional mismatch repair deficiency is crucial to diagnose cancer at an early stage or prevent cancer from occurring.

  • Research Article
    Circulating 27-hydroxycholesterol and Risk of Colorectal Adenomas and Serrated Polyps
    Michael N. Passarelli, Bonne M. Thompson, Jeffrey G. McDonald, Dale C. Snover, Thomas J. Palys, Judy R. Rees, Elizabeth L. Barry and John A. Baron
    Cancer Prev Res April 1 2021 14 (4) 479-488; DOI:10.1158/1940-6207.CAPR-20-0414

    This study found that plasma concentration of 27-hydroxycholesterol, a metabolite of cholesterol that regulates lipid metabolism and acts as a selective estrogen receptor modulator, is associated with the risk of developing precursor lesions for colorectal cancer.

  • Research Article | AuthorChoice
    Specificity of the Multi-Target Stool DNA Test for Colorectal Cancer Screening in Average-Risk 45–49 Year-Olds: A Cross-Sectional Study
    Thomas F. Imperiale, John B. Kisiel, Steven H. Itzkowitz, Bradley Scheu, Emma Kate Duimstra, Sandra Statz, Barry M. Berger and Paul J. Limburg
    Cancer Prev Res April 1 2021 14 (4) 489-496; DOI:10.1158/1940-6207.CAPR-20-0294

    This study shows that mt-sDNA has high specificity among average-risk 45–49 year olds, supporting its use as a non-invasive option for colorectal cancer screening.

  • Research Article | AuthorChoice
    Plasma and Urine Metabolite Profiles Impacted by Increased Dietary Navy Bean Intake in Colorectal Cancer Survivors: A Randomized-Controlled Trial
    Iman Zarei, Bridget A. Baxter, Renee C. Oppel, Erica C. Borresen, Regina J. Brown and Elizabeth P. Ryan
    Cancer Prev Res April 1 2021 14 (4) 497-508; DOI:10.1158/1940-6207.CAPR-20-0270

    This clinical study suggests that increased consumption of navy beans would deliver bioactive metabolites to individuals at high risk for colorectal cancer recurrence and produce metabolic shifts in plasma and urine profiles.

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Cancer Prevention Research: 14 (4)
April 2021
Volume 14, Issue 4
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Issue Highlights

  • Germline Pathogenic Variants in the Ataxia Telangiectasia Mutated (ATM) Gene are Associated with High and Moderate Risks for Multiple Cancers

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  • Breast Cancer Mortality in the Women's Health Initiative
  • DNA Methylation and Gastric Cancer
  • HPV-positive and -Negative Cervical Precancers
  • Adipose–tumor Crosstalk in Patients with CRC: A Multi-omics Study
  • Anticancer Pharmacology of WA in Breast Cancer
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Cancer Prevention Research
eISSN: 1940-6215
ISSN: 1940-6207

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