Table of Contents

Research Articles

• Research Article

  The Role of Forkhead Box Q1 Transcription Factor in Anticancer Effects of Withaferin A in Breast Cancer

  Su-Hyeong Kim, Krishna B. Singh, Eun-Ryeong Hahm and Shivendra V. Singh

  Cancer Prev Res April 1 2021 14 (4) 421-432; DOI:10.1158/1940-6207.CAPR-20-0590

  
  

  Withaferin A (WA) is highly effective in reducing burden and/or incidence of breast cancer in various preclinical models. However, the mechanism underlying breast cancer prevention byWA is not fully understood. This study shows a role for FoxQ1 in antitumor response to WA.
• Research Article | AuthorChoice

  Germline Pathogenic Variants in the Ataxia Telangiectasia Mutated (ATM) Gene are Associated with High and Moderate Risks for Multiple Cancers

  Michael J. Hall, Ryan Bernhisel, Elisha Hughes, Katie Larson, Eric T. Rosenthal, Nanda A. Singh, Johnathan M. Lancaster and Allison W. Kurian

  Cancer Prev Res April 1 2021 14 (4) 433-440; DOI:10.1158/1940-6207.CAPR-20-0448

  
  

  This study estimated risks for multiple cancers associated with ATM pathogenic variants independent of family history. These results indicate that some common variants may be associated with higher breast cancer risks than previously appreciated and increased screening for prostate and gastric cancer may be warranted for carriers of ATM pathogenic variants.
• Research Article

  Functional Common and Rare ERBB2 Germline Variants Cooperate in Familial and Sporadic Cancer Susceptibility

  Riyue Bao, Anita Ng, Mark Sasaki, Myvizhi Esai Selvan, Alyna Katti, Hyesan Lee, Lei Huang, Andrew D. Skol, Cinzia Lavarino, Hector Salvador, Robert J. Klein, Zeynep H. Gümüş, Jaume Mora and Kenan Onel

  Cancer Prev Res April 1 2021 14 (4) 441-454; DOI:10.1158/1940-6207.CAPR-20-0094

  
  

  By performing whole-exome sequencing on germline DNA from multiple cancer-affected individuals belonging to a family in which multiple cancer types track across three generations, we identified and then characterized functional common and rare variation in ERBB2 associated with both sporadic and familial cancer. Our results suggest that heritable variation activating ERBB2 signaling is associated with risk for multiple cancer types, with increases in signaling correlated with increases in risk, and modified by ancestry or family history.
• Research Article

  Cost Effectiveness of Whole Population BRCA Genetic Screening for Cancer Prevention in Israel

  Nadav Michaan, Moshe Leshno, Tamar Safra, Amir Sonnenblick, Ido Laskov and Dan Grisaru

  Cancer Prev Res April 1 2021 14 (4) 455-462; DOI:10.1158/1940-6207.CAPR-20-0411

  
  

  Whole population BRCA mutation screening in Israel is cost effective across a wide prevalence rate and should be offered as part of general health screening strategies by national medical insurance providers for cancer prevention.
• Research Article

  Obesity is Associated with Shorter Telomere Length in Prostate Stromal Cells in Men with Aggressive Prostate Cancer

  Corinne E. Joshu, Christopher M. Heaphy, John R. Barber, Jiayun Lu, Reza Zarinshenas, Christine Davis, Misop Han, Tamara L. Lotan, Karen S. Sfanos, Angelo M. De Marzo, Alan K. Meeker and Elizabeth A. Platz

  Cancer Prev Res April 1 2021 14 (4) 463-470; DOI:10.1158/1940-6207.CAPR-20-0250

  
  

  This study investigates a potential mechanism underlying the association between obesity and prostate cancer death. Among men with aggressive prostate cancer, obesity was associated with shorter telomeres prostate cancer associated stromal cells, and shorter CAS telomeres have been associated with an increased risk of prostate cancer death.
• Research Article

  A Retrospective Chart Review of Children in Neurocutaneous Clinic Who May Benefit from Further Evaluation Beyond Neurofibromatosis Type I

  Stephanie R. Hicks, Amanda K. Cozart, Gary A. Bellus and Kami W. Schneider

  Cancer Prev Res April 1 2021 14 (4) 471-478; DOI:10.1158/1940-6207.CAPR-20-0373

  
  

  This study suggests that at-risk population with a suspected NF1 diagnosis may benefit from further evaluation. Correct diagnosis of constitutional mismatch repair deficiency is crucial to diagnose cancer at an early stage or prevent cancer from occurring.
• Research Article

  Circulating 27-hydroxycholesterol and Risk of Colorectal Adenomas and Serrated Polyps

  Michael N. Passarelli, Bonne M. Thompson, Jeffrey G. McDonald, Dale C. Snover, Thomas J. Palys, Judy R. Rees, Elizabeth L. Barry and John A. Baron

  Cancer Prev Res April 1 2021 14 (4) 479-488; DOI:10.1158/1940-6207.CAPR-20-0414

  
  

  This study found that plasma concentration of 27-hydroxycholesterol, a metabolite of cholesterol that regulates lipid metabolism and acts as a selective estrogen receptor modulator, is associated with the risk of developing precursor lesions for colorectal cancer.
• Research Article | AuthorChoice

  Specificity of the Multi-Target Stool DNA Test for Colorectal Cancer Screening in Average-Risk 45–49 Year-Olds: A Cross-Sectional Study

  Thomas F. Imperiale, John B. Kisiel, Steven H. Itzkowitz, Bradley Scheu, Emma Kate Duimstra, Sandra Statz, Barry M. Berger and Paul J. Limburg

  Cancer Prev Res April 1 2021 14 (4) 489-496; DOI:10.1158/1940-6207.CAPR-20-0294

  
  

  This study shows that mt-sDNA has high specificity among average-risk 45–49 year olds, supporting its use as a non-invasive option for colorectal cancer screening.
• Research Article | AuthorChoice

  Plasma and Urine Metabolite Profiles Impacted by Increased Dietary Navy Bean Intake in Colorectal Cancer Survivors: A Randomized-Controlled Trial

  Iman Zarei, Bridget A. Baxter, Renee C. Oppel, Erica C. Borresen, Regina J. Brown and Elizabeth P. Ryan

  Cancer Prev Res April 1 2021 14 (4) 497-508; DOI:10.1158/1940-6207.CAPR-20-0270

  
  

  This clinical study suggests that increased consumption of navy beans would deliver bioactive metabolites to individuals at high risk for colorectal cancer recurrence and produce metabolic shifts in plasma and urine profiles.