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Cancer Prevention Research
Cancer Prevention Research
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Review

Metformin and Other Biguanides in Oncology: Advancing the Research Agenda

Michael Pollak
Michael Pollak
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DOI: 10.1158/1940-6207.CAPR-10-0175 Published September 2010
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Abstract

Retrospective studies that may be impractical to confirm prospectively suggest that diabetics treated with metformin have a substantially reduced cancer burden compared with other diabetics. It is unclear if this reflects a chemopreventive effect, an effect on transformed cells, or both. It also remains to be established if these data have relevance to people without diabetes. Laboratory models, however, provide independent impressive evidence for the activity of metformin and other biguanides in both cancer treatment and chemoprevention. Investigations of mechanisms of action of biguanides have revealed considerable complexity and have identified important gaps in knowledge that should be addressed to ensure the optimal design of clinical trials of these agents. Such trials may define important new indications for biguanides in the prevention and/or treatment of many common cancers. Cancer Prev Res; 3(9); 1060–5. ©2010 AACR.

  • Received July 20, 2010.
  • Revision received July 27, 2010.
  • Accepted July 27, 2010.
  • ©2010 American Association for Cancer Research.
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Cancer Prevention Research: 3 (9)
September 2010
Volume 3, Issue 9
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Metformin and Other Biguanides in Oncology: Advancing the Research Agenda
Michael Pollak
Cancer Prev Res September 1 2010 (3) (9) 1060-1065; DOI: 10.1158/1940-6207.CAPR-10-0175

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Metformin and Other Biguanides in Oncology: Advancing the Research Agenda
Michael Pollak
Cancer Prev Res September 1 2010 (3) (9) 1060-1065; DOI: 10.1158/1940-6207.CAPR-10-0175
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  • Article
    • Abstract
    • Introduction
    • Mechanisms of Actions of Biguanides for Current Indications
    • Metformin and Neoplastic Disease: Early Clues
    • Recent Findings Suggesting Oncologic Applications of Biguanides
    • Gaps in Knowledge
    • The Way Forward
    • Disclosure of Potential Conflicts of Interest
    • Acknowledgments
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Cancer Prevention Research
eISSN: 1940-6215
ISSN: 1940-6207

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