Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • "Best of" Collection
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Prevention Research
Cancer Prevention Research
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • "Best of" Collection
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Research Article

Chemoprevention of Colon Cancer in a Rat Carcinogenesis Model Using a Novel Nanotechnology-Based Combined Treatment System

Abhishek Chaudhary, Dhruvitkumar Sutaria, Ying Huang, Jeffrey Wang and Sunil Prabhu
Abhishek Chaudhary
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dhruvitkumar Sutaria
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ying Huang
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jeffrey Wang
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sunil Prabhu
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1158/1940-6207.CAPR-11-0129 Published October 2011
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Additional Files
  • Figure 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 1.

    Effect of unmodified combinations of ASP, FA and Ca (G3–G7) on the AOM-induced aberrant crypts in the rat colon. Statistical 2-way ANOVA analysis followed by a Bonferroni post hoc analyses for aberrant crypts distribution according to the position on colon (Set 1; *, P < 0.05; **, P < 0.001). AOM, azoxymethane.

  • Figure 2.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 2.

    Dose response curve from Set 1 and probit analysis (inset) to calculate the effective dose (ED50) for the range of doses used (G3–G7).

  • Figure 3.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 3.

    Effect of (A) unmodified combinations of ASP, FA and Ca (G10–G12) compared to the (B) modified NP combinations of chemopreventive agents (G13–G15). Statistical 2-way ANOVA analysis followed by a Bonferroni post hoc analyses for ACF distribution according to the position on colon (*, P < 0.05; **, P < 0.001)

  • Figure 4.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 4.

    Histochemical H&E stains of longitudinal sections of rat distal colon depicting the nuclear proliferation of cancer cells when observed under a light microscope (×40) for the control (G8–G9) and NP-treated groups (G13–G15).

  • Figure 5.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Figure 5.

    Effect of individual doses of NP-mediated single chemopreventive agent (G18–GS20) and that of a combined dose (G21) on ACF inhibition in the distal colon of rat. Statistical 2-way ANOVA analyses followed by a Bonferroni post hoc analysis for aberrant crypts distribution according to the position on colon (*, P < 0.05)

Tables

  • Figures
  • Additional Files
  • Table 1.

    Treatment plan showing groups of Sprague-Dawley rats treated with unmodified and nanoparticle forms of chemopreventive agents aspirin, folic acid, and calcium at various doses

    SetGroup (n = 6)Treatment planDose, mg/kg
    Set 1 (unmodified combination)G1Saline (control)0
    G2AOM (control)0
    G3ASP + FA + Ca400 + 32 + 650
    G4ASP + FA + Ca133 + 11 + 216
    G5ASP + FA + Ca40 + 3.2 + 65
    G6ASP + FA + Ca13 + 1.1 + 22
    G7ASP + FA + Ca4 + 0.32 + 6.5
    Set 2 (unmodified and modified combination)G8Saline (control)0
    G9AOM (control)0
    G10ASP + FA + Ca133 + 11 + 216
    G11ASP + FA + Ca80 + 6.4 + 130
    G12ASP + FA + Ca40 + 3.2 + 65
    G13ASP (NP) + FA (NP) + Ca133 + 11 + 216
    G14ASP (NP) + FA (NP) + Ca80 + 6.4 + 130
    G15ASP (NP) + FA (NP) + Ca40 + 3.2 + 65
    Set 3 (modified combination)G16Saline (control)0
    G17AOM (control)0
    G18ASP (NP)40
    G19FA (NP)3.2
    G20Ca65
    G21ASP (NP) + FA (NP) + Ca40 + 3.2 + 65

    Abbreviations: ASP, aspirin; AOM, azoxymethane; FA, folic acid; Ca, calcium; NP, nanoparticles.

    Additional Files

    • Figures
    • Tables
    • Supplementary Data

      Files in this Data Supplement:

      • Supplementary Figure A - PDF file - 120K
    PreviousNext
    Back to top
    Cancer Prevention Research: 4 (10)
    October 2011
    Volume 4, Issue 10
    • Table of Contents
    • Table of Contents (PDF)
    • About the Cover

    Sign up for alerts

    View this article with LENS

    Open full page PDF
    Article Alerts
    Sign In to Email Alerts with your Email Address
    Email Article

    Thank you for sharing this Cancer Prevention Research article.

    NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

    Enter multiple addresses on separate lines or separate them with commas.
    Chemoprevention of Colon Cancer in a Rat Carcinogenesis Model Using a Novel Nanotechnology-Based Combined Treatment System
    (Your Name) has forwarded a page to you from Cancer Prevention Research
    (Your Name) thought you would be interested in this article in Cancer Prevention Research.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Citation Tools
    Chemoprevention of Colon Cancer in a Rat Carcinogenesis Model Using a Novel Nanotechnology-Based Combined Treatment System
    Abhishek Chaudhary, Dhruvitkumar Sutaria, Ying Huang, Jeffrey Wang and Sunil Prabhu
    Cancer Prev Res October 1 2011 (4) (10) 1655-1664; DOI: 10.1158/1940-6207.CAPR-11-0129

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
    Share
    Chemoprevention of Colon Cancer in a Rat Carcinogenesis Model Using a Novel Nanotechnology-Based Combined Treatment System
    Abhishek Chaudhary, Dhruvitkumar Sutaria, Ying Huang, Jeffrey Wang and Sunil Prabhu
    Cancer Prev Res October 1 2011 (4) (10) 1655-1664; DOI: 10.1158/1940-6207.CAPR-11-0129
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
    • Tweet Widget
    • Facebook Like
    • Google Plus One

    Jump to section

    • Article
      • Abstract
      • Introduction
      • Materials and Methods
      • Results
      • Discussion
      • Disclosure of Potential Conflicts of Interest
      • Grant Support
      • Footnotes
      • References
    • Figures & Data
    • Info & Metrics
    • PDF
    Advertisement

    Related Articles

    Cited By...

    More in this TOC Section

    • Obesity and Telomere Length in Prostate Stromal Cells
    • Regulatory T Cells and Melanocytic Nevi
    • mt-sDNA Specificity in 45–49 Year-Olds
    Show more Research Articles
    • Home
    • Alerts
    • Feedback
    • Privacy Policy
    Facebook   Twitter   LinkedIn   YouTube   RSS

    Articles

    • Online First
    • Current Issue
    • Past Issues

    Info for

    • Authors
    • Subscribers
    • Advertisers
    • Librarians

    About Cancer Prevention Research

    • About the Journal
    • Editorial Board
    • Permissions
    • Submit a Manuscript
    AACR logo

    Copyright © 2021 by the American Association for Cancer Research.

    Cancer Prevention Research
    eISSN: 1940-6215
    ISSN: 1940-6207

    Advertisement