Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • "Best of" Collection
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Prevention Research
Cancer Prevention Research
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • "Best of" Collection
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Epidemiology/Lifestyle Factors

Abstract A86: Interaction of nitrate and folate on the risk of breast cancer among postmenopausal women

Maki Inoue-Choi, Mary H. Ward, James R. Cerhan, Peter J. Weyer, Kristin Anderson and Kim Robien
Maki Inoue-Choi
1University of Minnesota, Minneapolis, MN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mary H. Ward
2National Cancer Institute, Bethesda, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James R. Cerhan
3Mayo Clinic, Rochester, MN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter J. Weyer
4University of Iowa, Coralville, IA.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kristin Anderson
1University of Minnesota, Minneapolis, MN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kim Robien
1University of Minnesota, Minneapolis, MN
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1158/1940-6207.PREV-11-A86 Published October 2011
  • Article
  • Info & Metrics
Loading
Abstracts: AACR International Conference on Frontiers in Cancer Prevention Research‐‐ Oct 22-25, 2011; Boston, MA

Abstract

Background: Ingested nitrate can form N-nitroso compounds endogenously, which may lead to DNA adducts and activating mutations in oncogenes. However, previous studies have reported null or inverse associations between dietary nitrate intake and cancer risk, while nitrate intake from drinking water has shown null or positive associations with cancer risk. These associations may be confounded by protective effects of dietary folate, which provides methyl groups for nucleotide synthesis, and thus plays a vital role in the DNA repair system. In a small case-control study, an increased risk of breast cancer was observed among individuals with high dietary nitrate relative to folate intake. We therefore evaluated interaction of total folate with nitrate intake from diet and drinking water on breast cancer risk in the Iowa Women's Health Study (IWHS).

Methods: The IWHS is a prospective cohort study of cancer among 41,836 women in Iowa, initiated in 1986. Dietary intake was assessed at study baseline using a food frequency questionnaire (FFQ). Nitrate intake from foods and total folate intake from foods and dietary supplements were computed using consumption frequencies collected by the FFQ. Nitrate intake from drinking water was assessed using a historical analytical database on Iowa municipal water supplies in 15,151 women using municipal water supply. We evaluated the interaction of nitrate and total folate intake with breast cancer risk using Cox proportional hazard regression modeling, adjusting for potential confounders (age, body mass index, waist-hip-ratio, education, smoking, family history of breast cancer, age at menopause, age at first live birth, estrogen use, total energy intake, and intake of vitamin C and E and flavonoids).

Results: After baseline exclusions (history of cancer at baseline, previous mastectomy or partial breast resection, implausible energy intake, or ≥30 missing responses on the FFQ), there were 34,388 postmenopausal women in the analytic cohort. Through 2008, 2,875 incident breast cancer cases were identified. Nitrate intake from diet or drinking water was not associated with breast cancer risk. After stratification by total folate intake, high dietary nitrate intake (>106.1 mg/day) was associated with a marginally decreased risk of breast cancer compared to those with low nitrate intake (≤106.1 mg/day) (HR=0.90, 95% confidence interval=0.81–1.00) only among women with folate intake <400 μg/day (p for interaction = 0.65). There was no interaction of nitrate intake from drinking water and total folate intake on breast cancer risk.

Conclusions: Our findings do not support the previously reported increased risk of breast cancer risk among individuals with high dietary nitrate and low folate intake. The inverse association between nitrate intake and breast cancer risk observed among women with low folate intake in the present study may be attributed to residual confounding due to high correlation among intakes of nitrate, folate and antioxidants.

Citation Information: Cancer Prev Res 2011;4(10 Suppl):A86.

  • Copyright © American Association for Cancer Research
Previous
Back to top
Cancer Prevention Research: 4 (10 Supplement)
October 2011
Volume 4, Issue 10 Supplement
  • Table of Contents

Sign up for alerts

Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Prevention Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Abstract A86: Interaction of nitrate and folate on the risk of breast cancer among postmenopausal women
(Your Name) has forwarded a page to you from Cancer Prevention Research
(Your Name) thought you would be interested in this article in Cancer Prevention Research.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Abstract A86: Interaction of nitrate and folate on the risk of breast cancer among postmenopausal women
Maki Inoue-Choi, Mary H. Ward, James R. Cerhan, Peter J. Weyer, Kristin Anderson and Kim Robien
Cancer Prev Res October 1 2011 (4) (10 Supplement) A86; DOI: 10.1158/1940-6207.PREV-11-A86

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Abstract A86: Interaction of nitrate and folate on the risk of breast cancer among postmenopausal women
Maki Inoue-Choi, Mary H. Ward, James R. Cerhan, Peter J. Weyer, Kristin Anderson and Kim Robien
Cancer Prev Res October 1 2011 (4) (10 Supplement) A86; DOI: 10.1158/1940-6207.PREV-11-A86
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Info & Metrics
Advertisement

Related Articles

Cited By...

More in this TOC Section

Epidemiology/Lifestyle Factors

  • Abstract PR12: Adolescent inflammation and body mass index in relation to colorectal cancer risk
  • Abstract PL05-01: Obesity, IGF-1 and cancer prevention: Mechanistic insights from transdisciplinary studies
  • Abstract PL04-03: Evidence for increased muscle breakdown associated with early pancreatic cancer
Show more Epidemiology/Lifestyle Factors

Other Molecular Epidemiology

  • Abstract A49: Meta-analysis of vitamin D-binding protein and cancer risk
  • Abstract A81: Germline polymorphisms associated with survival in patients with non-small cell lung cancer
Show more Other Molecular Epidemiology

Other Molecular Epidemiology: Poster Presentations - Proffered Abstracts

  • Abstract A49: Meta-analysis of vitamin D-binding protein and cancer risk
  • Abstract A81: Germline polymorphisms associated with survival in patients with non-small cell lung cancer
  • Abstract A86: Interaction of nitrate and folate on the risk of breast cancer among postmenopausal women
Show more Other Molecular Epidemiology: Poster Presentations - Proffered Abstracts
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook   Twitter   LinkedIn   YouTube   RSS

Articles

  • Online First
  • Current Issue
  • Past Issues

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Prevention Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Prevention Research
eISSN: 1940-6215
ISSN: 1940-6207

Advertisement