Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

AACR logo

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Must- Read Articles
      • "Best of" Collection
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Prevention Research
Cancer Prevention Research
  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • COVID-19 & Cancer Resource Center
      • Must- Read Articles
      • "Best of" Collection
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • Editors' Picks
    • OnlineFirst
    • Citation
    • Author/Keyword
    • RSS Feeds
    • My Alert Summary & Preferences
  • News
    • Cancer Discovery News
  • COVID-19
  • Webinars
  • Search More

    Advanced Search

Research Article

Bioavailability of Sulforaphane from Two Broccoli Sprout Beverages: Results of a Short-term, Cross-over Clinical Trial in Qidong, China

Patricia A. Egner, Jian Guo Chen, Jin Bing Wang, Yan Wu, Yan Sun, Jian Hua Lu, Jian Zhu, Yong Hui Zhang, Yong Sheng Chen, Marlin D. Friesen, Lisa P. Jacobson, Alvaro Muñoz, Derek Ng, Geng Sun Qian, Yuan Rong Zhu, Tao Yang Chen, Nigel P. Botting, Qingzhi Zhang, Jed W. Fahey, Paul Talalay, John D Groopman and Thomas W. Kensler
Patricia A. Egner
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jian Guo Chen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jin Bing Wang
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yan Wu
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yan Sun
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jian Hua Lu
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jian Zhu
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yong Hui Zhang
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yong Sheng Chen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marlin D. Friesen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lisa P. Jacobson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alvaro Muñoz
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Derek Ng
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Geng Sun Qian
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yuan Rong Zhu
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tao Yang Chen
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nigel P. Botting
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Qingzhi Zhang
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jed W. Fahey
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paul Talalay
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
John D Groopman
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas W. Kensler
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1158/1940-6207.CAPR-10-0296 Published March 2011
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

One of several challenges in design of clinical chemoprevention trials is the selection of the dose, formulation, and dose schedule of the intervention agent. Therefore, a cross-over clinical trial was undertaken to compare the bioavailability and tolerability of sulforaphane from two of broccoli sprout–derived beverages: one glucoraphanin-rich (GRR) and the other sulforaphane-rich (SFR). Sulforaphane was generated from glucoraphanin contained in GRR by gut microflora or formed by treatment of GRR with myrosinase from daikon (Raphanus sativus) sprouts to provide SFR. Fifty healthy, eligible participants were requested to refrain from crucifer consumption and randomized into two treatment arms. The study design was as follows: 5-day run-in period, 7-day administration of beverages, 5-day washout period, and 7-day administration of the opposite intervention. Isotope dilution mass spectrometry was used to measure levels of glucoraphanin, sulforaphane, and sulforaphane thiol conjugates in urine samples collected daily throughout the study. Bioavailability, as measured by urinary excretion of sulforaphane and its metabolites (in approximately 12-hour collections after dosing), was substantially greater with the SFR (mean = 70%) than with GRR (mean = 5%) beverages. Interindividual variability in excretion was considerably lower with SFR than with GRR beverage. Elimination rates were considerably slower with GRR, allowing for achievement of steady-state dosing as opposed to bolus dosing with SFR. Optimal dosing formulations in future studies should consider blends of sulforaphane and glucoraphanin as SFR and GRR mixtures to achieve peak concentrations for activation of some targets and prolonged inhibition of others implicated in the protective actions of sulforaphane. Cancer Prev Res; 4(3); 384–95. ©2011 AACR.

Footnotes

  • Note: Supplementary data for this article are available at Cancer Prevention Research Online (http://cancerprevres.aacrjournals.org/).

  • Received October 22, 2010.
  • Revision received January 11, 2011.
  • Accepted January 15, 2011.
  • ©2011 American Association for Cancer Research.
View Full Text
PreviousNext
Back to top
Cancer Prevention Research: 4 (3)
March 2011
Volume 4, Issue 3
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover

Sign up for alerts

View this article with LENS

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Prevention Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Bioavailability of Sulforaphane from Two Broccoli Sprout Beverages: Results of a Short-term, Cross-over Clinical Trial in Qidong, China
(Your Name) has forwarded a page to you from Cancer Prevention Research
(Your Name) thought you would be interested in this article in Cancer Prevention Research.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Bioavailability of Sulforaphane from Two Broccoli Sprout Beverages: Results of a Short-term, Cross-over Clinical Trial in Qidong, China
Patricia A. Egner, Jian Guo Chen, Jin Bing Wang, Yan Wu, Yan Sun, Jian Hua Lu, Jian Zhu, Yong Hui Zhang, Yong Sheng Chen, Marlin D. Friesen, Lisa P. Jacobson, Alvaro Muñoz, Derek Ng, Geng Sun Qian, Yuan Rong Zhu, Tao Yang Chen, Nigel P. Botting, Qingzhi Zhang, Jed W. Fahey, Paul Talalay, John D Groopman and Thomas W. Kensler
Cancer Prev Res March 1 2011 (4) (3) 384-395; DOI: 10.1158/1940-6207.CAPR-10-0296

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Bioavailability of Sulforaphane from Two Broccoli Sprout Beverages: Results of a Short-term, Cross-over Clinical Trial in Qidong, China
Patricia A. Egner, Jian Guo Chen, Jin Bing Wang, Yan Wu, Yan Sun, Jian Hua Lu, Jian Zhu, Yong Hui Zhang, Yong Sheng Chen, Marlin D. Friesen, Lisa P. Jacobson, Alvaro Muñoz, Derek Ng, Geng Sun Qian, Yuan Rong Zhu, Tao Yang Chen, Nigel P. Botting, Qingzhi Zhang, Jed W. Fahey, Paul Talalay, John D Groopman and Thomas W. Kensler
Cancer Prev Res March 1 2011 (4) (3) 384-395; DOI: 10.1158/1940-6207.CAPR-10-0296
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Materials and Methods
    • Results
    • Discussion
    • Disclosure of Potential Conflicts of Interest
    • Grant Support
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Oral Health and Upper Gastrointestinal Cancers
  • HCC Early Detection
  • Utility of Germline SNPs in Prostate Cancer Diagnosis
Show more Research Articles
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook   Twitter   LinkedIn   YouTube   RSS

Articles

  • Online First
  • Current Issue
  • Past Issues

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians

About Cancer Prevention Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2021 by the American Association for Cancer Research.

Cancer Prevention Research
eISSN: 1940-6215
ISSN: 1940-6207

Advertisement