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Cancer Prevention Research
Cancer Prevention Research
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Research Article

Circulating Levels of Vitamin D and Colon and Rectal Cancer: The Physicians' Health Study and a Meta-analysis of Prospective Studies

Jung Eun Lee, Haojie Li, Andrew T. Chan, Bruce W. Hollis, I-Min Lee, Meir J. Stampfer, Kana Wu, Edward Giovannucci and Jing Ma
Jung Eun Lee
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Haojie Li
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Andrew T. Chan
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Bruce W. Hollis
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I-Min Lee
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Meir J. Stampfer
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Kana Wu
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Edward Giovannucci
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Jing Ma
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DOI: 10.1158/1940-6207.CAPR-10-0289 Published May 2011
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Abstract

It remains unknown whether increased risk with low levels of vitamin D is present for colon and/or rectal cancer. To investigate the association between circulating vitamin D levels and colon and rectal cancer, we examined the associations between plasma levels of 25-hydroxyvitamin D [25(OH)D] and 1,25-dihydroxyvitamin D [1,25(OH)2D] and colon and rectal cancer in the Physicians' Health Study and then conducted a meta-analysis of eight prospective studies of circulating levels of 25(OH)D and colon and rectal cancers, including the Physicians' Health Study. Study-specific ORs and 95% CIs were pooled by using a random-effects model. A total of 1,822 colon and 868 rectal cancers were included in the meta-analysis. We observed a significant inverse association for colorectal cancer (OR = 0.66; 95% CI, 0.54–0.81), comparing top versus bottom quantiles of circulating 25(OH)D levels. The inverse association was stronger for rectal cancer (OR = 0.50 for top versus bottom quantiles; 95% CI, 0.28–0.88) than colon cancer (OR = 0.77; 95% CI, 0.56–1.07; P value for difference between colon and rectal cancer = 0.20). These data suggest an inverse association between circulating 25(OH)D levels and colorectal cancer, with a stronger association for rectal cancer. Cancer Prev Res; 4(5); 735–43. ©2011 AACR.

  • Received October 19, 2010.
  • Revision received January 25, 2011.
  • Accepted March 15, 2011.
  • ©2011 American Association for Cancer Research.
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Cancer Prevention Research: 4 (5)
May 2011
Volume 4, Issue 5
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Circulating Levels of Vitamin D and Colon and Rectal Cancer: The Physicians' Health Study and a Meta-analysis of Prospective Studies
Jung Eun Lee, Haojie Li, Andrew T. Chan, Bruce W. Hollis, I-Min Lee, Meir J. Stampfer, Kana Wu, Edward Giovannucci and Jing Ma
Cancer Prev Res May 1 2011 (4) (5) 735-743; DOI: 10.1158/1940-6207.CAPR-10-0289

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Circulating Levels of Vitamin D and Colon and Rectal Cancer: The Physicians' Health Study and a Meta-analysis of Prospective Studies
Jung Eun Lee, Haojie Li, Andrew T. Chan, Bruce W. Hollis, I-Min Lee, Meir J. Stampfer, Kana Wu, Edward Giovannucci and Jing Ma
Cancer Prev Res May 1 2011 (4) (5) 735-743; DOI: 10.1158/1940-6207.CAPR-10-0289
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