Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citation
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Prevention Research
Cancer Prevention Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citation
    • Author/Keyword
  • News
    • Cancer Discovery News
Research Article

Antiestrogen Therapy for Breast Cancer Modifies the Risk of Subsequent Cutaneous Melanoma

Caroline Huber, Christine Bouchardy, Robin Schaffar, Isabelle Neyroud-Caspar, Georges Vlastos, Frédérique-Anne Le Gal, Elisabetta Rapiti and Simone Benhamou
Caroline Huber
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christine Bouchardy
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robin Schaffar
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Isabelle Neyroud-Caspar
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Georges Vlastos
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Frédérique-Anne Le Gal
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elisabetta Rapiti
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Simone Benhamou
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1158/1940-6207.CAPR-11-0332 Published January 2012
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Increased risk of secondary melanoma after breast cancer has been reported. Several lines of evidence suggest that elevated estrogen levels may be implicated in melanoma etiology. Accordingly, use of antiestrogens should be associated with decreased risk of melanoma. We compared melanoma incidence among a cohort of breast cancer patients with and without antiestrogen therapy, with data from the Geneva Cancer Registry. The cohort consisted of 7,360 women diagnosed with breast cancer between 1980 and 2005. About 54% of these patients received antiestrogens. All women were followed until December 2008. We compared cutaneous melanoma incidence rates among patients with and without antiestrogens with those expected in the general population by age and period standardized incidence ratios (SIR). A total of 34 women developed a melanoma during the follow-up period. Compared with the general population, the risk of melanoma was higher for patients who did not receive antiestrogens (SIR: 1.60, 95% CI: 1.08–2.12, P = 0.02). On the contrary, the risk was close to 1 (SIR: 0.98, 95% CI: 0.40–1.56, P = 0.57) for patients who received antiestrogen therapy. This study suggests that antiestrogen therapy modifies the risk of melanoma after breast cancer. Although our results are in agreement with the hypothesis that estrogens could play a role in melanoma occurrence, they need to be replicated in a larger study with data on potential confounders. Cancer Prev Res; 5(1); 82–88. ©2011 AACR.

  • Received June 30, 2011.
  • Revision received August 19, 2011.
  • Accepted September 12, 2011.
  • ©2011 American Association for Cancer Research.
View Full Text
PreviousNext
Back to top
Cancer Prevention Research: 5 (1)
January 2012
Volume 5, Issue 1
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover

Sign up for alerts

View this article with LENS

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Prevention Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Antiestrogen Therapy for Breast Cancer Modifies the Risk of Subsequent Cutaneous Melanoma
(Your Name) has forwarded a page to you from Cancer Prevention Research
(Your Name) thought you would be interested in this article in Cancer Prevention Research.
Citation Tools
Antiestrogen Therapy for Breast Cancer Modifies the Risk of Subsequent Cutaneous Melanoma
Caroline Huber, Christine Bouchardy, Robin Schaffar, Isabelle Neyroud-Caspar, Georges Vlastos, Frédérique-Anne Le Gal, Elisabetta Rapiti and Simone Benhamou
Cancer Prev Res January 1 2012 (5) (1) 82-88; DOI: 10.1158/1940-6207.CAPR-11-0332

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Antiestrogen Therapy for Breast Cancer Modifies the Risk of Subsequent Cutaneous Melanoma
Caroline Huber, Christine Bouchardy, Robin Schaffar, Isabelle Neyroud-Caspar, Georges Vlastos, Frédérique-Anne Le Gal, Elisabetta Rapiti and Simone Benhamou
Cancer Prev Res January 1 2012 (5) (1) 82-88; DOI: 10.1158/1940-6207.CAPR-11-0332
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Introduction
    • Patients and Methods
    • Results
    • Discussion
    • Disclosure of Potential Conflicts of Interest
    • Grant Support
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Anthos prevent metabolic shifts from microbiome and B[a]P
  • Breast Cancer Characteristics and Survival
  • Community-based screening for gastric cancer
Show more Research Articles
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook   Twitter   LinkedIn   YouTube   RSS

Articles

  • Online First
  • Current Issue
  • Past Issues

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Prevention Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2019 by the American Association for Cancer Research.

Cancer Prevention Research
eISSN: 1940-6215
ISSN: 1940-6207

Advertisement