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Cancer Prevention Research
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Perspective

PPARγ Agonists Target Aromatase Via Both PGE2 and BRCA1

Ofer Margalit, Dingzhi Wang and Raymond N. DuBois
Ofer Margalit
Authors' Affiliations: Departments of 1Cancer Biology and 2Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
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Dingzhi Wang
Authors' Affiliations: Departments of 1Cancer Biology and 2Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
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Raymond N. DuBois
Authors' Affiliations: Departments of 1Cancer Biology and 2Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
Authors' Affiliations: Departments of 1Cancer Biology and 2Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas
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DOI: 10.1158/1940-6207.CAPR-12-0365 Published October 2012
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Abstract

Obesity is a well-recognized risk factor for postmenopausal breast cancer. Although the underlying mechanisms are not clearly defined, aromatase is thought to play a pivotal role in connecting obesity-associated inflammation with postmenopausal breast cancer. It has been well established that both the proinflammatory prostaglandin E2 (PGE2) and the BRCA1 tumor-suppressor gene regulate aromatase expression. In this issue of the journal (beginning on p. 1183), Subbaramaiah and colleagues improve our understanding of the molecular mechanisms by which PPARγ inhibits aromatase expression. They found that pioglitazone, a PPARγ agonist, inhibited aromatase expression by inhibition of PGE2 signaling and upregulation of BRCA1. Their findings provide potential targets for preventing or treating obesity-related breast cancer. Cancer Prev Res; 5(10); 1169–72. ©2012 AACR.

Perspective on Subbaramaiah et al., p. 1183

  • Received August 23, 2012.
  • Revision received August 27, 2012.
  • Accepted August 31, 2012.
  • ©2012 American Association for Cancer Research.
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Cancer Prevention Research: 5 (10)
October 2012
Volume 5, Issue 10
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PPARγ Agonists Target Aromatase Via Both PGE2 and BRCA1
Ofer Margalit, Dingzhi Wang and Raymond N. DuBois
Cancer Prev Res October 1 2012 (5) (10) 1169-1172; DOI: 10.1158/1940-6207.CAPR-12-0365

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PPARγ Agonists Target Aromatase Via Both PGE2 and BRCA1
Ofer Margalit, Dingzhi Wang and Raymond N. DuBois
Cancer Prev Res October 1 2012 (5) (10) 1169-1172; DOI: 10.1158/1940-6207.CAPR-12-0365
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Cancer Prevention Research
eISSN: 1940-6215
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