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Chemoprevention and Biological Therapies

Abstract PR-03: Aspirin mediated downregulation of Warburg kinase AKT1 in patients with Barrett's esophagus: Implications in neoplastic transformation

Navtej S. Buttar, Gary W. Falk, Cathrine J. DeMars, Sonia Chowdhury, Ahmed Elebiary, Anamay Sharma, Sidhartha Chaudhry, Nathan R. Foster, Katie L. Allen Ziegler, Yvonne Romero, Norman E. Marcon, Thomas Schnell, Douglas A. Corley, Prateek Sharma, Marcia R. Cruz-Correa, Chin Hur, David E. Fleischer, Amitabh Chak, Kenneth R. DeVault, David S. Weinberg, Gary Della’Zanna, Ellen Richmond, Thomas C. Smyrk, Sumithra Mandrekar and Paul J. Limburg
Navtej S. Buttar
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Gary W. Falk
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Cathrine J. DeMars
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Sonia Chowdhury
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Ahmed Elebiary
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Anamay Sharma
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Sidhartha Chaudhry
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Nathan R. Foster
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Katie L. Allen Ziegler
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Yvonne Romero
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Norman E. Marcon
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Thomas Schnell
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Douglas A. Corley
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Prateek Sharma
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Marcia R. Cruz-Correa
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Chin Hur
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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David E. Fleischer
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Amitabh Chak
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Kenneth R. DeVault
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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David S. Weinberg
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Gary Della’Zanna
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Ellen Richmond
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Thomas C. Smyrk
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Sumithra Mandrekar
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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Paul J. Limburg
1Mayo Clinic, Rochester, MN, 2University of Pennsylvania, Philadelphia, Pa, 3St. Michael's Hospital, Toronto, ON, Canada, 4Hines Veterans Administration, Hines, IL, 5Kaiser Permanente Medical Group, San Francisco, CA, 6Kansas City VA Medical Center, Kansas City, MO, 7University of Puerto Rico Cancer Center, San Juan, Pr, 8Massachusetts General Hospital, Boston, MA, 9Mayo Clinic, Scottsdale, AZ, 10University Hospitals Case Medical Center, Cleveland, OH, 11Mayo Clinic, Jacksonville, FL, 12Fox Chase Cancer Center, Philadelphia, PA, 13Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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DOI: 10.1158/1940-6207.PREV-12-PR-03 Published November 2012
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Abstract

Background: In patients with Barrett's esophagus, chronic reflux injury and inflammation are associated with esophageal adenocarcinoma, one of the most rapidly increasing lethal cancers. Epidemiological and preclinical studies support decreased risk of esophageal adenocarcinoma with NSAID use. Gastroesophageal refluxate contents can promote carcinogenesis in Barrett's metaplasia by activating AKT, which up regulates COX-2 expression and prostaglandin biosynthesis. We recently noted that neoplastic transformation in Barrett's esophagus is associated with increased AKT expression, particularly isoform AKT1.

The AIM of this study is to investigate the effect of NSAID (Aspirin) use in patients with Barrett's esophagus on AKT1 expression using frozen tissue from the randomized, phase II trial of aspirin and esomeprazole for esophageal cancer chemoprevention in Barrett's esophagus patients and to assess the functional consequences of AKT1 expression in-vitro.

Methods and Results: In a subset of patients (12 of 120 patients) with Barrett's esophagus who were randomized to placebo, lower dose (81 mg) or higher dose (325 mg) Aspirin for 4 weeks, both PCR and Western blot revealed marked reduction in AKT1 expression in patients who received 325 mg of Aspirin daily compared to patients who received placebo. Our in-vitro experiments support that AKT1 expression is functionally relevant to the process of carcinogenesis in Barrett's epithelial cells. Using adenovirus to induce AKT1 expression, we show that increased AKT1 expression increases Barrett's epithelial cell growth, facilitates RAS-mediated transformation of pre-neoplastic epithelial cells and promotes colony formation. Since AKT1 is known as Warburg kinase and regulates cellular glucose uptake to support aerobic glycolysis during growth de-regulation and neoplasia, we examined the uptake of fluorescent deoxyglucose analog (2-NBDG) in Barrett's epithelial cells transduced with AKT1 adenovirus. At 48 hrs, compared to control, AKT1 overexpression resulted in increased glucose uptake both by metaplastic and neoplastic Barrett's epithelial cells. Transcriptional repression of AKT1 abrogated the 2-NBDG uptake by these cells. Finally, we did pathway specific qPCRs and noted that use of Aspirin is associated with altered expression of chromatin remodelers that could down-regulate AKT1 expression.

Conclusion: Collectively, our results demonstrate that Aspirin mediated down-regulation of Warburg kinase AKT1 in patients with Barrett?s esophagus is a novel mechanism for the regulation of Barrett?s epithelial cell growth. The in-depth characterization of molecular mechanisms is currently underway.

This abstract is also presented as Poster A82.

Citation Format: Navtej S. Buttar, Gary W. Falk, Cathrine J. DeMars, Sonia Chowdhury, Ahmed Elebiary, Anamay Sharma, Sidhartha Chaudhry, Nathan R. Foster, Katie L. Allen Ziegler, Yvonne Romero, Norman E. Marcon, Thomas Schnell, Douglas A. Corley, Prateek Sharma, Marcia R. Cruz-Correa, Chin Hur, David E. Fleischer, Amitabh Chak, Kenneth R. DeVault, David S. Weinberg, Gary Della’Zanna, Ellen Richmond, Thomas C. Smyrk, Sumithra Mandrekar, Paul J. Limburg. Aspirin mediated downregulation of Warburg kinase AKT1 in patients with Barrett's esophagus: Implications in neoplastic transformation. [abstract]. In: Proceedings of the Eleventh Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2012 Oct 16-19; Anaheim, CA. Philadelphia (PA): AACR; Cancer Prev Res 2012;5(11 Suppl):Abstract nr PR-03.

  • ©2012 American Association for Cancer Research.
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Cancer Prevention Research: 5 (11 Supplement)
November 2012
Volume 5, Issue 11 Supplement
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Abstract PR-03: Aspirin mediated downregulation of Warburg kinase AKT1 in patients with Barrett's esophagus: Implications in neoplastic transformation
Navtej S. Buttar, Gary W. Falk, Cathrine J. DeMars, Sonia Chowdhury, Ahmed Elebiary, Anamay Sharma, Sidhartha Chaudhry, Nathan R. Foster, Katie L. Allen Ziegler, Yvonne Romero, Norman E. Marcon, Thomas Schnell, Douglas A. Corley, Prateek Sharma, Marcia R. Cruz-Correa, Chin Hur, David E. Fleischer, Amitabh Chak, Kenneth R. DeVault, David S. Weinberg, Gary Della’Zanna, Ellen Richmond, Thomas C. Smyrk, Sumithra Mandrekar and Paul J. Limburg
Cancer Prev Res November 1 2012 (5) (11 Supplement) PR-03; DOI: 10.1158/1940-6207.PREV-12-PR-03

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Abstract PR-03: Aspirin mediated downregulation of Warburg kinase AKT1 in patients with Barrett's esophagus: Implications in neoplastic transformation
Navtej S. Buttar, Gary W. Falk, Cathrine J. DeMars, Sonia Chowdhury, Ahmed Elebiary, Anamay Sharma, Sidhartha Chaudhry, Nathan R. Foster, Katie L. Allen Ziegler, Yvonne Romero, Norman E. Marcon, Thomas Schnell, Douglas A. Corley, Prateek Sharma, Marcia R. Cruz-Correa, Chin Hur, David E. Fleischer, Amitabh Chak, Kenneth R. DeVault, David S. Weinberg, Gary Della’Zanna, Ellen Richmond, Thomas C. Smyrk, Sumithra Mandrekar and Paul J. Limburg
Cancer Prev Res November 1 2012 (5) (11 Supplement) PR-03; DOI: 10.1158/1940-6207.PREV-12-PR-03
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