Table of Contents

Research Articles

• Research Article | Free Article

  Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage

  Carolyn Algire, Olga Moiseeva, Xavier Deschênes-Simard, Lilian Amrein, Luca Petruccelli, Elena Birman, Benoit Viollet, Gerardo Ferbeyre and Michael N. Pollak

  Cancer Prev Res April 1 2012 5 (4) 536-543; DOI:10.1158/1940-6207.CAPR-11-0536

  
  
• Research Article

  Metformin Prevents Liver Tumorigenesis by Inhibiting Pathways Driving Hepatic Lipogenesis

  Kavita Bhalla, Bor Jang Hwang, Ruby E. Dewi, William Twaddel, Olga G. Goloubeva, Kwok-Kin Wong, Neeraj K. Saxena, Shyam Biswal and Geoffrey D. Girnun

  Cancer Prev Res April 1 2012 5 (4) 544-552; DOI:10.1158/1940-6207.CAPR-11-0228

  
  
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  Metformin-Mediated Bambi Expression in Hepatic Stellate Cells Induces Prosurvival Wnt/β-Catenin Signaling

  Nanthakumar Subramaniam, Mara H. Sherman, Renuka Rao, Caroline Wilson, Sally Coulter, Annette R. Atkins, Ronald M. Evans, Christopher Liddle and Michael Downes

  Cancer Prev Res April 1 2012 5 (4) 553-561; DOI:10.1158/1940-6207.CAPR-12-0053

  
  
• Research Article

  Metformin Prevents the Development of Oral Squamous Cell Carcinomas from Carcinogen-Induced Premalignant Lesions

  Lynn Vitale-Cross, Alfredo A. Molinolo, Daniel Martin, Rania H. Younis, Takashi Maruyama, Vyomesh Patel, Wanjun Chen, Abraham Schneider and J. Silvio Gutkind

  Cancer Prev Res April 1 2012 5 (4) 562-573; DOI:10.1158/1940-6207.CAPR-11-0502

  
  
• Research Article

  Microsatellite Instability and DNA Mismatch Repair Protein Deficiency in Lynch Syndrome Colorectal Polyps

  Matthew B. Yurgelun, Ajay Goel, Jason L. Hornick, Ananda Sen, Danielle Kim Turgeon, Mack T. Ruffin IV, Norman E. Marcon, John A. Baron, Robert S. Bresalier, Sapna Syngal, Dean E. Brenner, C. Richard Boland and Elena M. Stoffel

  Cancer Prev Res April 1 2012 5 (4) 574-582; DOI:10.1158/1940-6207.CAPR-11-0519

  
  
• Research Article

  Body Mass Index and the Risk for Developing Invasive Breast Cancer among High-Risk Women in NSABP P-1 and STAR Breast Cancer Prevention Trials

  Reena S. Cecchini, Joseph P. Costantino, Jane A. Cauley, Walter M. Cronin, D. Lawrence Wickerham, Stephanie R. Land, Joel L. Weissfeld and Norman Wolmark

  Cancer Prev Res April 1 2012 5 (4) 583-592; DOI:10.1158/1940-6207.CAPR-11-0482

  
  
• Research Article

  Carnosol, a Constituent of Zyflamend, Inhibits Aryl Hydrocarbon Receptor–Mediated Activation of CYP1A1 and CYP1B1 Transcription and Mutagenesis

  Arash Mohebati, Joseph B. Guttenplan, Amit Kochhar, Zhong-Lin Zhao, Wieslawa Kosinska, Kotha Subbaramaiah and Andrew J. Dannenberg

  Cancer Prev Res April 1 2012 5 (4) 593-602; DOI:10.1158/1940-6207.CAPR-12-0002

  
  
• Research Article

  Protection of Humans by Plant Glucosinolates: Efficiency of Conversion of Glucosinolates to Isothiocyanates by the Gastrointestinal Microflora

  Jed W. Fahey, Scott L. Wehage, W. David Holtzclaw, Thomas W. Kensler, Patricia A. Egner, Theresa A. Shapiro and Paul Talalay

  Cancer Prev Res April 1 2012 5 (4) 603-611; DOI:10.1158/1940-6207.CAPR-11-0538

  
  
• Research Article

  The Novel Akt Inhibitor API-1 Induces c-FLIP Degradation and Synergizes with TRAIL to Augment Apoptosis Independent of Akt Inhibition

  Bo Li, Hui Ren, Ping Yue, Mingwei Chen, Fadlo R. Khuri and Shi-Yong Sun

  Cancer Prev Res April 1 2012 5 (4) 612-620; DOI:10.1158/1940-6207.CAPR-11-0548

  
  
• Research Article

  A Phase 2 Cancer Chemoprevention Biomarker Trial of Isoflavone G-2535 (Genistein) in Presurgical Bladder Cancer Patients

  Edward Messing, Jason R. Gee, Daniel R. Saltzstein, KyungMann Kim, Anthony diSant'Agnese, Jill Kolesar, Linda Harris, Adrienne Faerber, Thomas Havighurst, Jay M. Young, Mitchell Efros, Robert H. Getzenberg, Marcia A. Wheeler, Joseph Tangrea, Howard Parnes, Margaret House, J. Erik Busby, Raymond Hohl and Howard Bailey

  Cancer Prev Res April 1 2012 5 (4) 621-630; DOI:10.1158/1940-6207.CAPR-11-0455

  
  
• Research Article

  Celastrol Suppresses Growth and Induces Apoptosis of Human Hepatocellular Carcinoma through the Modulation of STAT3/JAK2 Signaling Cascade In Vitro and In Vivo

  Peramaiyan Rajendran, Feng Li, Muthu K. Shanmugam, Radhamani Kannaiyan, Jen Nee Goh, Kwong Fai Wong, Wei Wang, Ester Khin, Vinay Tergaonkar, Alan Prem Kumar, John M. Luk and Gautam Sethi

  Cancer Prev Res April 1 2012 5 (4) 631-643; DOI:10.1158/1940-6207.CAPR-11-0420

  
  
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  δ- and γ-Tocopherols, but not α-Tocopherol, Inhibit Colon Carcinogenesis in Azoxymethane-Treated F344 Rats

  Fei Guan, Guangxun Li, Anna B. Liu, Mao-Jung Lee, Zhihong Yang, Yu-Kuo Chen, Yong Lin, Weichung Shih and Chung S. Yang

  Cancer Prev Res April 1 2012 5 (4) 644-654; DOI:10.1158/1940-6207.CAPR-11-0521

  
  
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  Increased Plasma Levels of the APC-Interacting Protein MAPRE1, LRG1, and IGFBP2 Preceding a Diagnosis of Colorectal Cancer in Women

  Jon J. Ladd, Tina Busald, Melissa M. Johnson, Qing Zhang, Sharon J. Pitteri, Hong Wang, Dean E. Brenner, Paul D. Lampe, Raju Kucherlapati, Ziding Feng, Ross L. Prentice and Samir M. Hanash

  Cancer Prev Res April 1 2012 5 (4) 655-664; DOI:10.1158/1940-6207.CAPR-11-0412

  
  
• Research Article

  Oncogenic Function and Early Detection Potential of miRNA-10b in Oral Cancer as Identified by microRNA Profiling

  Ya-Ching Lu, Yin-Ju Chen, Hung-Ming Wang, Chi-Ying Tsai, Wen-Ho Chen, Yu-Chen Huang, Kang-Hsing Fan, Chi-Neu Tsai, Shiang-Fu Huang, Chung-Jan Kang, Joseph Tung-Chieh Chang and Ann-Joy Cheng

  Cancer Prev Res April 1 2012 5 (4) 665-674; DOI:10.1158/1940-6207.CAPR-11-0358

  
  
• Research Article

  A New Biomarker That Predicts Colonic Neoplasia Outcome in Patients with Hyperplastic Colonic Polyps

  Catherine Do, Claudine Bertrand, Julien Palasse, Marie-Bernadette Delisle, Arthur Shulkes, Elizabeth Cohen-Jonathan-Moyal, Audrey Ferrand and Catherine Seva

  Cancer Prev Res April 1 2012 5 (4) 675-684; DOI:10.1158/1940-6207.CAPR-11-0408

  
  
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  A Hexane Fraction of American Ginseng Suppresses Mouse Colitis and Associated Colon Cancer: Anti-inflammatory and Proapoptotic Mechanisms

  Deepak Poudyal, Phuong Mai Le, Tia Davis, Anne B. Hofseth, Alena Chumanevich, Alexander A. Chumanevich, Michael J. Wargovich, Mitzi Nagarkatti, Prakash S. Nagarkatti, Anthony Windust and Lorne J. Hofseth

  Cancer Prev Res April 1 2012 5 (4) 685-696; DOI:10.1158/1940-6207.CAPR-11-0421