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Cancer Prevention Research
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Research Article

The Novel Akt Inhibitor API-1 Induces c-FLIP Degradation and Synergizes with TRAIL to Augment Apoptosis Independent of Akt Inhibition

Bo Li, Hui Ren, Ping Yue, Mingwei Chen, Fadlo R. Khuri and Shi-Yong Sun
Bo Li
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Hui Ren
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Ping Yue
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Mingwei Chen
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Fadlo R. Khuri
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Shi-Yong Sun
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DOI: 10.1158/1940-6207.CAPR-11-0548 Published April 2012
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Article Information

Volume 5, Issue 4, pp. 612-620

DOI 
https://doi.org/10.1158/1940-6207.CAPR-11-0548
PubMed 
22345097

Published By 
American Association for Cancer Research
Print ISSN 
1940-6207
Online ISSN 
1940-6215
History 
  • Received November 30, 2011
  • Revision received January 16, 2012
  • Accepted February 8, 2012
  • Published first February 16, 2012.

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  • Previous version (February 16, 2012 - 06:23).
  • Previous version (March 2, 2012 - 07:01).
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©2012 American Association for Cancer Research.

Author Information

  1. Bo Li1,2,
  2. Hui Ren1,3,
  3. Ping Yue1,
  4. Mingwei Chen3,
  5. Fadlo R. Khuri1, and
  6. Shi-Yong Sun1
  1. Authors' Affiliations: 1Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia; 2Department of Pathology, Xiangya Medical School, Central South University, Changsha, Hunan; and 3Department of Respiration, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China
  1. Corresponding Author:
    Shi-Yong Sun, Emory University School of Medicine, Winship Cancer Institute, 1365-C Clifton Road NE, C-3088, Atlanta, GA 30322. Phone: 404-778-2170; Fax: 404-778-5520; E-mail: ssun{at}emory.edu
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Cancer Prevention Research: 5 (4)
April 2012
Volume 5, Issue 4
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The Novel Akt Inhibitor API-1 Induces c-FLIP Degradation and Synergizes with TRAIL to Augment Apoptosis Independent of Akt Inhibition
Bo Li, Hui Ren, Ping Yue, Mingwei Chen, Fadlo R. Khuri and Shi-Yong Sun
Cancer Prev Res April 1 2012 (5) (4) 612-620; DOI: 10.1158/1940-6207.CAPR-11-0548

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The Novel Akt Inhibitor API-1 Induces c-FLIP Degradation and Synergizes with TRAIL to Augment Apoptosis Independent of Akt Inhibition
Bo Li, Hui Ren, Ping Yue, Mingwei Chen, Fadlo R. Khuri and Shi-Yong Sun
Cancer Prev Res April 1 2012 (5) (4) 612-620; DOI: 10.1158/1940-6207.CAPR-11-0548
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