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Cancer Prevention Research
Cancer Prevention Research
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Research Article

Inositol Hexaphosphate Inhibits Tumor Growth, Vascularity, and Metabolism in TRAMP Mice: A Multiparametric Magnetic Resonance Study

Komal Raina, Kameswaran Ravichandran, Subapriya Rajamanickam, Kendra M. Huber, Natalie J. Serkova and Rajesh Agarwal
Komal Raina
1Department of Pharmaceutical Sciences, Skaggs School of Pharmacy; 2Department of Anesthesiology; and 3University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado
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Kameswaran Ravichandran
1Department of Pharmaceutical Sciences, Skaggs School of Pharmacy; 2Department of Anesthesiology; and 3University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado
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Subapriya Rajamanickam
1Department of Pharmaceutical Sciences, Skaggs School of Pharmacy; 2Department of Anesthesiology; and 3University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado
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Kendra M. Huber
1Department of Pharmaceutical Sciences, Skaggs School of Pharmacy; 2Department of Anesthesiology; and 3University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado
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Natalie J. Serkova
1Department of Pharmaceutical Sciences, Skaggs School of Pharmacy; 2Department of Anesthesiology; and 3University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado
1Department of Pharmaceutical Sciences, Skaggs School of Pharmacy; 2Department of Anesthesiology; and 3University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado
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Rajesh Agarwal
1Department of Pharmaceutical Sciences, Skaggs School of Pharmacy; 2Department of Anesthesiology; and 3University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado
1Department of Pharmaceutical Sciences, Skaggs School of Pharmacy; 2Department of Anesthesiology; and 3University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado
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DOI: 10.1158/1940-6207.CAPR-12-0387 Published January 2013
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Abstract

Herein, employing anatomical and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), we evaluated noninvasively, the in vivo, chemopreventive efficacy of inositol hexaphosphate (IP6), a major constituent of high-fiber diets, against prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate (TRAMP) model. Male TRAMP mice, beginning at 4 weeks of age, were fed with 1%, 2%, or 4% (w/v) IP6 in drinking water or only drinking water till 28 weeks of age and monitored using MRI over the course of study. Longitudinal assessment of prostate volumes by conventional MRI and tumor vascularity by gadolinium-based DCE-MRI showed a profound reduction in tumor size, partly due to antiangiogenic effects by IP6 treatment. As potential mechanisms of IP6 efficacy, decrease in the expression of glucose transporter GLUT-4 protein together with an increase in levels of phospho-AMP-activated kinase (AMPKTh172) were observed in prostate tissues of mice from IP6 fed-groups, suggesting that IP6 is interfering with the metabolic events occurring in TRAMP prostate. Investigative metabolomics study using quantitative high-resolution 1H-NMR on prostate tissue extracts showed that IP6 significantly decreased glucose metabolism and membrane phospholipid synthesis, in addition to causing an increase in myoinositol levels in the prostate. Together, these findings show that oral IP6 supplement blocks growth and angiogenesis of prostate cancer in the TRAMP model in conjunction with metabolic events involved in tumor sustenance. This results in energy deprivation within the tumor, suggesting a practical and translational potential of IP6 treatment in suppressing growth and progression of prostate cancer in humans. Cancer Prev Res; 6(1); 40–50; ©2012 AACR.

Footnotes

  • Note: Supplementary data for this article are available at Cancer Prevention Research Online (http://cancerprevres.aacrjournals.org/).

  • Received September 12, 2012.
  • Revision received November 9, 2012.
  • Accepted November 20, 2012.
  • ©2012 American Association for Cancer Research.
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Cancer Prevention Research: 6 (1)
January 2013
Volume 6, Issue 1
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Inositol Hexaphosphate Inhibits Tumor Growth, Vascularity, and Metabolism in TRAMP Mice: A Multiparametric Magnetic Resonance Study
Komal Raina, Kameswaran Ravichandran, Subapriya Rajamanickam, Kendra M. Huber, Natalie J. Serkova and Rajesh Agarwal
Cancer Prev Res January 1 2013 (6) (1) 40-50; DOI: 10.1158/1940-6207.CAPR-12-0387

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Inositol Hexaphosphate Inhibits Tumor Growth, Vascularity, and Metabolism in TRAMP Mice: A Multiparametric Magnetic Resonance Study
Komal Raina, Kameswaran Ravichandran, Subapriya Rajamanickam, Kendra M. Huber, Natalie J. Serkova and Rajesh Agarwal
Cancer Prev Res January 1 2013 (6) (1) 40-50; DOI: 10.1158/1940-6207.CAPR-12-0387
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