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Cancer Prevention Research
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Research Article

Assessing the Breast Cancer Risk Distribution for Women Undergoing Screening in British Columbia

Christina R. Weisstock, Rasika Rajapakshe, Christabelle Bitgood, Steven McAvoy, Paula B. Gordon, Andrew J. Coldman, Brent A. Parker and Christine Wilson
Christina R. Weisstock
1BC Cancer Agency, Medical Physics, Kelowna, BC; 2University of British Columbia, Southern Medical Program, Kelowna, BC; 3BC Women's Hospital & Health Centre, Sadie Diamond Breast Program, Vancouver, BC; 4BC Cancer Agency, Population Oncology, Vancouver, BC; and 5BC Cancer Agency, Diagnostic Imaging, Vancouver, BC
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Rasika Rajapakshe
1BC Cancer Agency, Medical Physics, Kelowna, BC; 2University of British Columbia, Southern Medical Program, Kelowna, BC; 3BC Women's Hospital & Health Centre, Sadie Diamond Breast Program, Vancouver, BC; 4BC Cancer Agency, Population Oncology, Vancouver, BC; and 5BC Cancer Agency, Diagnostic Imaging, Vancouver, BC
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Christabelle Bitgood
1BC Cancer Agency, Medical Physics, Kelowna, BC; 2University of British Columbia, Southern Medical Program, Kelowna, BC; 3BC Women's Hospital & Health Centre, Sadie Diamond Breast Program, Vancouver, BC; 4BC Cancer Agency, Population Oncology, Vancouver, BC; and 5BC Cancer Agency, Diagnostic Imaging, Vancouver, BC
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Steven McAvoy
1BC Cancer Agency, Medical Physics, Kelowna, BC; 2University of British Columbia, Southern Medical Program, Kelowna, BC; 3BC Women's Hospital & Health Centre, Sadie Diamond Breast Program, Vancouver, BC; 4BC Cancer Agency, Population Oncology, Vancouver, BC; and 5BC Cancer Agency, Diagnostic Imaging, Vancouver, BC
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Paula B. Gordon
1BC Cancer Agency, Medical Physics, Kelowna, BC; 2University of British Columbia, Southern Medical Program, Kelowna, BC; 3BC Women's Hospital & Health Centre, Sadie Diamond Breast Program, Vancouver, BC; 4BC Cancer Agency, Population Oncology, Vancouver, BC; and 5BC Cancer Agency, Diagnostic Imaging, Vancouver, BC
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Andrew J. Coldman
1BC Cancer Agency, Medical Physics, Kelowna, BC; 2University of British Columbia, Southern Medical Program, Kelowna, BC; 3BC Women's Hospital & Health Centre, Sadie Diamond Breast Program, Vancouver, BC; 4BC Cancer Agency, Population Oncology, Vancouver, BC; and 5BC Cancer Agency, Diagnostic Imaging, Vancouver, BC
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Brent A. Parker
1BC Cancer Agency, Medical Physics, Kelowna, BC; 2University of British Columbia, Southern Medical Program, Kelowna, BC; 3BC Women's Hospital & Health Centre, Sadie Diamond Breast Program, Vancouver, BC; 4BC Cancer Agency, Population Oncology, Vancouver, BC; and 5BC Cancer Agency, Diagnostic Imaging, Vancouver, BC
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Christine Wilson
1BC Cancer Agency, Medical Physics, Kelowna, BC; 2University of British Columbia, Southern Medical Program, Kelowna, BC; 3BC Women's Hospital & Health Centre, Sadie Diamond Breast Program, Vancouver, BC; 4BC Cancer Agency, Population Oncology, Vancouver, BC; and 5BC Cancer Agency, Diagnostic Imaging, Vancouver, BC
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DOI: 10.1158/1940-6207.CAPR-13-0027 Published October 2013
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Abstract

Breast cancer risk estimations are both informative and useful at the population level, with many screening programs relying on these assessments to allocate resources such as breast MRI. This cross-sectional multicenter study attempts to quantify the breast cancer risk distribution for women between the ages of 40 to 79 years undergoing screening mammography in British Columbia (BC), Canada. The proportion of women at high breast cancer risk was estimated by surveying women enrolled in the Screening Mammography Program of British Columbia (SMPBC) for known breast cancer risk factors. Each respondent's 10-year risk was computed with both the Tyrer–Cuzick and Gail risk assessment models. The resulting risk distributions were evaluated using the guidelines from the National Institute for Health and Care Excellence (United Kingdom). Of the 4,266 women surveyed, 3.5% of women between the ages of 40 to 79 years were found to have a high 10-year risk of developing breast cancer using the Tyrer–Cuzick model (1.1% using the Gail model). When extrapolated to the screening population, it was estimated that 19,414 women in the SMPBC are considered to be at high breast cancer risk. These women may benefit from additional MRI screening; preliminary analysis suggests that 4 to 5 additional MRI machines would be required to screen these high-risk women. However, the use of different models and guidelines will modify the number of women qualifying for additional screening interventions, thus impacting the MRI resources required. The results of this project can now be used to inform decision-making groups about resource allocation for breast cancer screening in BC. Cancer Prev Res; 6(10); 1084–92. ©2013 AACR.

Footnotes

  • Note: Supplementary data for this article are available at Cancer Prevention Research Online (http://cancerprevres.aacrjournals.org/).

  • Received January 29, 2013.
  • Revision received July 18, 2013.
  • Accepted August 1, 2013.
  • ©2013 American Association for Cancer Research.
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Cancer Prevention Research: 6 (10)
October 2013
Volume 6, Issue 10
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Assessing the Breast Cancer Risk Distribution for Women Undergoing Screening in British Columbia
Christina R. Weisstock, Rasika Rajapakshe, Christabelle Bitgood, Steven McAvoy, Paula B. Gordon, Andrew J. Coldman, Brent A. Parker and Christine Wilson
Cancer Prev Res October 1 2013 (6) (10) 1084-1092; DOI: 10.1158/1940-6207.CAPR-13-0027

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Assessing the Breast Cancer Risk Distribution for Women Undergoing Screening in British Columbia
Christina R. Weisstock, Rasika Rajapakshe, Christabelle Bitgood, Steven McAvoy, Paula B. Gordon, Andrew J. Coldman, Brent A. Parker and Christine Wilson
Cancer Prev Res October 1 2013 (6) (10) 1084-1092; DOI: 10.1158/1940-6207.CAPR-13-0027
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