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Cancer Prevention Research
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Research Article

Cost-effectiveness of a Genetic Test for Breast Cancer Risk

Henry J. Folse, Linda E. Green, Andrea Kress, Richard Allman and Tuan A. Dinh
Henry J. Folse
1Archimedes, Inc., San Francisco; 2Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California; and 3Genetic Technologies, Ltd., Fitzroy, Victoria, Australia
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Linda E. Green
1Archimedes, Inc., San Francisco; 2Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California; and 3Genetic Technologies, Ltd., Fitzroy, Victoria, Australia
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Andrea Kress
1Archimedes, Inc., San Francisco; 2Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California; and 3Genetic Technologies, Ltd., Fitzroy, Victoria, Australia
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Richard Allman
1Archimedes, Inc., San Francisco; 2Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California; and 3Genetic Technologies, Ltd., Fitzroy, Victoria, Australia
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Tuan A. Dinh
1Archimedes, Inc., San Francisco; 2Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California; and 3Genetic Technologies, Ltd., Fitzroy, Victoria, Australia
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DOI: 10.1158/1940-6207.CAPR-13-0056 Published December 2013
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Abstract

Genetic testing of seven single-nucleotide polymorphisms (7SNP) can improve estimates of risk of breast cancer relative to the Gail risk test alone, for the purpose of recommending MRI screening for women at high risk. A simulation of breast cancer and health care processes was used to conduct a virtual trial comparing the use of the 7SNP test with the Gail risk test to categorize patients by risk. Average-risk patients received annual mammogram, whereas high-risk patients received annual MRI. Cancer incidence was based on Surveillance, Epidemiology, and End Results data and validated to Cancer Prevention Study II Nutrition Cohort data. Risk factor values were drawn from National Health and Nutrition Examination Survey (NHANES-4) and Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial data. Mammogram characteristics were derived from Breast Cancer Surveillance Consortium data. The test was most cost-effective when given to patients at an intermediate lifetime risk of breast cancer. For patients with a risk of 16% to 28%, it resulted in a 1.91% reduction in cancer deaths, saving 0.005 quality-adjusted life years per person at a cost of $163,264 per QALY. These results were sensitive to the age at which the test is given, the discount rate, and the costs of the genetic test and MRI. The cost effectiveness of using the 7SNP test for patients with intermediate Gail risk is similar to that of other recommended strategies, including annual MRI for patients with a lifetime risk greater than 20% or BRCA1/2 mutations. Cancer Prev Res; 6(12); 1328–36. ©2013 AACR.

  • Received February 19, 2013.
  • Revision received August 7, 2013.
  • Accepted September 7, 2013.
  • ©2013 American Association for Cancer Research.
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Cancer Prevention Research: 6 (12)
December 2013
Volume 6, Issue 12
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Cost-effectiveness of a Genetic Test for Breast Cancer Risk
Henry J. Folse, Linda E. Green, Andrea Kress, Richard Allman and Tuan A. Dinh
Cancer Prev Res December 1 2013 (6) (12) 1328-1336; DOI: 10.1158/1940-6207.CAPR-13-0056

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Cost-effectiveness of a Genetic Test for Breast Cancer Risk
Henry J. Folse, Linda E. Green, Andrea Kress, Richard Allman and Tuan A. Dinh
Cancer Prev Res December 1 2013 (6) (12) 1328-1336; DOI: 10.1158/1940-6207.CAPR-13-0056
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