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Cancer Prevention Research
Cancer Prevention Research
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Perspective

Get the Fat Out!

Natalia A. Ignatenko and Eugene W. Gerner
Natalia A. Ignatenko
1Department of Cellular and Molecular Medicine; 2Arizona Cancer Center; and 3BIO5 Institute, University of Arizona, Tucson, Arizona
1Department of Cellular and Molecular Medicine; 2Arizona Cancer Center; and 3BIO5 Institute, University of Arizona, Tucson, Arizona
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Eugene W. Gerner
1Department of Cellular and Molecular Medicine; 2Arizona Cancer Center; and 3BIO5 Institute, University of Arizona, Tucson, Arizona
1Department of Cellular and Molecular Medicine; 2Arizona Cancer Center; and 3BIO5 Institute, University of Arizona, Tucson, Arizona
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DOI: 10.1158/1940-6207.CAPR-13-0025 Published March 2013
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    Figure 1.

    Relationships between mutant APC signaling pathways and experimental interventions, including caloric restriction and visceral fat removal in male and female mice. AMPK, 5′ adenosine monophosphate-activated protein kinase; IKKβ-NF-κB, inhibitor of NF-κB; CXCL-1, chemokine (C-X-C motif) ligand 1; c-MYC, oncogene; ERK, extracellular signal-regulated kinase; ROS, reactive oxygen species; PKC, protein kinase C; LPL, lipoprotein lipase.

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    This Perspective refers to the following article:
    Abdominal Obesity, Independent from Caloric Intake, Accounts for the Development of Intestinal Tumors in Apc1638N/+ Female Mice
    Derek M. Huffman, Leonard H. Augenlicht, Xueying Zhang, John J. Lofrese, Gil Atzmon, John P. Chamberland, and Christos S. Mantzoros

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    Cancer Prevention Research: 6 (3)
    March 2013
    Volume 6, Issue 3
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    Get the Fat Out!
    Natalia A. Ignatenko and Eugene W. Gerner
    Cancer Prev Res March 1 2013 (6) (3) 161-164; DOI: 10.1158/1940-6207.CAPR-13-0025

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    Get the Fat Out!
    Natalia A. Ignatenko and Eugene W. Gerner
    Cancer Prev Res March 1 2013 (6) (3) 161-164; DOI: 10.1158/1940-6207.CAPR-13-0025
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