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Cancer Prevention Research
Cancer Prevention Research
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Editorial

Tonsillectomy and Risk of Oropharyngeal Cancer: Implications for Research and Prevention

Anil K. Chaturvedi
Anil K. Chaturvedi
Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.
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  • For correspondence: chaturva@mail.nih.gov
DOI: 10.1158/1940-6207.CAPR-15-0135 Published July 2015
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Abstract

The association of tonsillectomy, a common surgical procedure involving the removal of a majority of the palatine tonsillar tissue, with risk of tonsil cancer specifically or oropharyngeal cancers overall is not known. In this issue of Cancer Prevention Research, Fakhry and colleagues conduct an analysis within the Danish Cancer Registry and show that tonsillectomies were associated with significantly reduced risk of tonsil cancer, but were unrelated to risk of base of tongue cancers. This editorial discusses the implications of the results by Fakhry and colleagues for key prevailing questions in the field related to risk, rising incidence, secondary prevention, and treatment of oropharyngeal cancers. Cancer Prev Res; 8(7); 577–9. ©2015 AACR.

See related article by Fakhry et al., p. 583

  • Received April 1, 2015.
  • Accepted April 2, 2015.
  • ©2015 American Association for Cancer Research.
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Cancer Prevention Research: 8 (7)
July 2015
Volume 8, Issue 7
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Tonsillectomy and Risk of Oropharyngeal Cancer: Implications for Research and Prevention
Anil K. Chaturvedi
Cancer Prev Res July 1 2015 (8) (7) 577-579; DOI: 10.1158/1940-6207.CAPR-15-0135

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Tonsillectomy and Risk of Oropharyngeal Cancer: Implications for Research and Prevention
Anil K. Chaturvedi
Cancer Prev Res July 1 2015 (8) (7) 577-579; DOI: 10.1158/1940-6207.CAPR-15-0135
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    • Abstract
    • Do tonsillectomies reduce risk of HPV-positive cancers, HPV-negative cancers, or both?
    • Is the effect of tonsillectomy on oropharyngeal cancer risk differential by age?
    • Does a decline in tonsillectomies explain the rise in tonsil cancer incidence in recent years?
    • What are the implications for secondary prevention through prophylactic tonsillectomies?
    • What are the implications for treatment of oropharyngeal cancers?
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Cancer Prevention Research
eISSN: 1940-6215
ISSN: 1940-6207

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