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Cancer Prevention Research
Cancer Prevention Research
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Commentary

Foodstuffs for Preventing Cancer: The Preclinical and Clinical Development of Berries

Gary D. Stoner
Gary D. Stoner
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DOI: 10.1158/1940-6207.CAPR-08-0226
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Abstract

Laboratory research involving berries is a promising example of food-based cancer prevention. Berries contain many known chemopreventive agents such as anthocyanins and ellagitannins that can be greatly concentrated in freeze-dried berry powders. Based on our program of berry research, this commentary presents the first reported stepwise scheme for the preclinical and clinical development of foodstuffs for cancer prevention. Our preclinical work within this scheme includes promising approaches for assessing the chemopreventive potential of berry powder and berry extracts in preclinical model systems, for determining the mechanisms of action of these agents, and for identifying the active constituents in berries. The commentary also presents preliminary results of clinical trials in the oral cavity, esophagus, and colon using various formulations of freeze-dried berries. The relative merits of berry powders, extracts, or individual constituents (anthocyanins) for cancer prevention are also discussed.

Keywords
  • Chemoprevention
  • berries
  • esophagus
  • colon
  • animal
  • human

Footnotes

  • Grant support: NIH R01 grants CA096130 and CA103180 and U.S. Department of Agriculture grants 38903-03560 and 38903-19245 to the Ohio Agricultural Research and Development Center.

    • Received December 4, 2008.
    • Revision received January 29, 2009.
    • Accepted February 2, 2009.
  • ©2009 American Association for Cancer Research.
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This OnlineFirst version was published on March 3, 2009
doi: 10.1158/1940-6207.CAPR-08-0226

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Foodstuffs for Preventing Cancer: The Preclinical and Clinical Development of Berries
Gary D. Stoner
Cancer Prev Res March 3 2009 DOI: 10.1158/1940-6207.CAPR-08-0226

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Foodstuffs for Preventing Cancer: The Preclinical and Clinical Development of Berries
Gary D. Stoner
Cancer Prev Res March 3 2009 DOI: 10.1158/1940-6207.CAPR-08-0226
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Cancer Prevention Research
eISSN: 1940-6215
ISSN: 1940-6207

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