Skip to main content
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

  • Register
  • Log in
  • My Cart
Advertisement

Main menu

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citation
    • Author/Keyword
  • News
    • Cancer Discovery News
  • AACR Publications
    • Blood Cancer Discovery
    • Cancer Discovery
    • Cancer Epidemiology, Biomarkers & Prevention
    • Cancer Immunology Research
    • Cancer Prevention Research
    • Cancer Research
    • Clinical Cancer Research
    • Molecular Cancer Research
    • Molecular Cancer Therapeutics

User menu

  • Register
  • Log in
  • My Cart

Search

  • Advanced search
Cancer Prevention Research
Cancer Prevention Research

Advanced Search

  • Home
  • About
    • The Journal
    • AACR Journals
    • Subscriptions
    • Permissions and Reprints
    • Reviewing
  • Articles
    • OnlineFirst
    • Current Issue
    • Past Issues
    • Meeting Abstracts
    • Collections
      • Editors' Picks
  • For Authors
    • Information for Authors
    • Author Services
    • Best of: Author Profiles
    • Submit
  • Alerts
    • Table of Contents
    • OnlineFirst
    • Editors' Picks
    • Citation
    • Author/Keyword
  • News
    • Cancer Discovery News
Research Article

A Dietary Tomato Supplement Prevents Prostate Cancer in TRAMP Mice

Tania Pannellini, Manuela Iezzi, Marcella Liberatore, Federica Sabatini, Stefano Iacobelli, Cosmo Rossi, Saverio Alberti, Carmine Di Ilio, Paola Vitaglione, Vincenzo Fogliano and Mauro Piantelli
Tania Pannellini
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Manuela Iezzi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marcella Liberatore
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Federica Sabatini
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stefano Iacobelli
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Cosmo Rossi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Saverio Alberti
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carmine Di Ilio
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Paola Vitaglione
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vincenzo Fogliano
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mauro Piantelli
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1158/1940-6207.CAPR-09-0237
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Transgenic adenocarcinoma of the mouse prostate (TRAMP) is a model for progressive prostate cancer that mirrors the stages of the human form. In this study, the effects of a diet enriched with processed whole tomatoes on survival, tumorigenesis, and progression of prostate cancer, and the antioxidant and inflammatory status of TRAMP mice were investigated. Tomato diet significantly increased overall survival (P < 0.01), delayed progression from prostatic intraepithelial neoplasia to adenocarcinoma, and decreased the incidence of poorly differentiated carcinoma. Biochemical data disclosed an increase in serum antioxidant activity and a reduction of serum inflammation/angiogenesis biomarkers of particular importance in prostate carcinogenesis. Cancer Prev Res; 3(10); OF1–8. ©2010 AACR.

Footnotes

  • Note: Supplementary data for this article are available at Cancer Prevention Research Online (http://cancerprevres.aacrjournals.org/).

  • Received November 9, 2009.
  • Revision received June 8, 2010.
  • Accepted June 13, 2010.
  • ©2010 American Association for Cancer Research.
Next
Back to top

Published OnlineFirst September 14, 2010
doi: 10.1158/1940-6207.CAPR-09-0237

Open full page PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Cancer Prevention Research article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
A Dietary Tomato Supplement Prevents Prostate Cancer in TRAMP Mice
(Your Name) has forwarded a page to you from Cancer Prevention Research
(Your Name) thought you would be interested in this article in Cancer Prevention Research.
Citation Tools
A Dietary Tomato Supplement Prevents Prostate Cancer in TRAMP Mice
Tania Pannellini, Manuela Iezzi, Marcella Liberatore, Federica Sabatini, Stefano Iacobelli, Cosmo Rossi, Saverio Alberti, Carmine Di Ilio, Paola Vitaglione, Vincenzo Fogliano and Mauro Piantelli
Cancer Prev Res September 14 2010 DOI: 10.1158/1940-6207.CAPR-09-0237

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
A Dietary Tomato Supplement Prevents Prostate Cancer in TRAMP Mice
Tania Pannellini, Manuela Iezzi, Marcella Liberatore, Federica Sabatini, Stefano Iacobelli, Cosmo Rossi, Saverio Alberti, Carmine Di Ilio, Paola Vitaglione, Vincenzo Fogliano and Mauro Piantelli
Cancer Prev Res September 14 2010 DOI: 10.1158/1940-6207.CAPR-09-0237
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Advertisement

Related Articles

Cited By...

More in this TOC Section

  • Anthos prevent metabolic shifts from microbiome and B[a]P
  • Breast Cancer Characteristics and Survival
  • Community-based screening for gastric cancer
Show more Research Articles
  • Home
  • Alerts
  • Feedback
  • Privacy Policy
Facebook   Twitter   LinkedIn   YouTube   RSS

Articles

  • Online First
  • Current Issue
  • Past Issues

Info for

  • Authors
  • Subscribers
  • Advertisers
  • Librarians
  • Reviewers

About Cancer Prevention Research

  • About the Journal
  • Editorial Board
  • Permissions
  • Submit a Manuscript
AACR logo

Copyright © 2019 by the American Association for Cancer Research.

Cancer Prevention Research
eISSN: 1940-6215
ISSN: 1940-6207

Advertisement